Cell atlas - NAGA - The Human Protein Atlas

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NAGA

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	NAGA
Gene description	N-acetylgalactosaminidase, alpha-
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NAGA (HGNC Symbol)
Synonyms	D22S674
Description	N-acetylgalactosaminidase, alpha- (HGNC Symbol)
Entrez gene summary	NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	42058354 - 42070842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198951 (version 83.38)
Entrez gene	4668
UniProt	P17050 (UniProt - Evidence at protein level)
neXtProt	NX_P17050
Antibodypedia	NAGA antibodies

PROTEIN BROWSER

NAGA-001	NAGA-002	NAGA-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAGA-001 ENSP00000384603 ENST00000402937	P17050 [Direct mapping] Alpha-N-acetylgalactosaminidase A0A024R1Q5 [Target identity:100%; Query identity:100%] N-acetylgalactosaminidase, alpha-, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004557 [alpha-galactosidase activity] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0008456 [alpha-N-acetylgalactosaminidase activity] GO:0009311 [oligosaccharide metabolic process] GO:0016052 [carbohydrate catabolic process] GO:0016139 [glycoside catabolic process] GO:0019377 [glycolipid catabolic process] GO:0042803 [protein homodimerization activity] GO:0046477 [glycosylceramide catabolic process] GO:0070062 [extracellular exosome] Show all	411 aa 46.6 kDa	Yes	0
NAGA-002 ENSP00000379680 ENST00000396398	P17050 [Direct mapping] Alpha-N-acetylgalactosaminidase A0A024R1Q5 [Target identity:100%; Query identity:100%] N-acetylgalactosaminidase, alpha-, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004557 [alpha-galactosidase activity] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0008456 [alpha-N-acetylgalactosaminidase activity] GO:0009311 [oligosaccharide metabolic process] GO:0016052 [carbohydrate catabolic process] GO:0016139 [glycoside catabolic process] GO:0019377 [glycolipid catabolic process] GO:0042803 [protein homodimerization activity] GO:0046477 [glycosylceramide catabolic process] GO:0070062 [extracellular exosome] Show all	411 aa 46.6 kDa	Yes	0
NAGA-003 ENSP00000385283 ENST00000403363	P17050 [Direct mapping] Alpha-N-acetylgalactosaminidase A0A024R1Q5 [Target identity:100%; Query identity:100%] N-acetylgalactosaminidase, alpha-, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004557 [alpha-galactosidase activity] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0008456 [alpha-N-acetylgalactosaminidase activity] GO:0009311 [oligosaccharide metabolic process] GO:0016052 [carbohydrate catabolic process] GO:0016139 [glycoside catabolic process] GO:0019377 [glycolipid catabolic process] GO:0042803 [protein homodimerization activity] GO:0046477 [glycosylceramide catabolic process] GO:0070062 [extracellular exosome] Show all	411 aa 46.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.