Tissue expression of SGMS1 - Summary - The Human Protein Atlas

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SGMS1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SGMS1
Gene description	Sphingomyelin synthase 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression, most abundant in squamous epithelia.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA045191
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SGMS1 (HGNC Symbol)
Synonyms	MGC17342, MOB, SMS1, TMEM23
Description	Sphingomyelin synthase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q11.23
Chromosome location (bp)	50305586 - 50625163
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198964 (version 83.38)
Entrez gene	259230
UniProt
neXtProt
Antibodypedia	SGMS1 antibodies

PROTEIN BROWSER

SGMS1-002	SGMS1-003	SGMS1-005	SGMS1-201	SGMS1-202	SGMS1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGMS1-002 ENSP00000475427 ENST00000602565	U3KQ11 [Direct mapping] Phosphatidylcholine:ceramide cholinephosphotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		12 aa 1.6 kDa	No	0
SGMS1-003 ENSP00000354829 ENST00000361781	D3DWC4 [Direct mapping] Phosphatidylcholine:ceramide cholinephosphotransferase 1; Transmembrane protein 23, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006954 [inflammatory response] GO:0010628 [positive regulation of gene expression] GO:0016021 [integral component of membrane] GO:0071222 [cellular response to lipopolysaccharide] GO:0071356 [cellular response to tumor necrosis factor] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	413 aa 48.6 kDa	No	6
SGMS1-005 ENSP00000473668 ENST00000602619	R4GNI5 [Direct mapping] Phosphatidylcholine:ceramide cholinephosphotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4.1 kDa	No	0
SGMS1-201 ENSP00000355235 ENST00000361543	C0MHM2 [Direct mapping] Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	241 aa 27.6 kDa	No	3
SGMS1-202 ENSP00000406795 ENST00000429490	E6ZCI6 [Direct mapping] Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	219 aa 25.3 kDa	No	2
SGMS1-203 ENSP00000479633 ENST00000619438	C0MHM2 [Direct mapping] Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	241 aa 27.6 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.