Cell atlas - COX20 - The Human Protein Atlas

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COX20

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	COX20
Gene description	COX20 cytochrome c oxidase assembly factor
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA043617 , HPA045490
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA043617	A-431	Mitochondria
HPA043617	U-2 OS	Mitochondria
HPA043617	U-251 MG	Mitochondria
HPA045490	A-431	Mitochondria
HPA045490	U-2 OS	Mitochondria
HPA045490	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	COX20 (HGNC Symbol)
Synonyms	FAM36A, FLJ43269
Description	COX20 cytochrome c oxidase assembly factor (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Chromosome	1
Cytoband	q44
Chromosome location (bp)	244835322 - 244845057
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203667 (version 83.38)
Entrez gene	116228
UniProt	Q5RI15 (UniProt - Evidence at protein level)
neXtProt	NX_Q5RI15
Antibodypedia	COX20 antibodies

PROTEIN BROWSER

COX20-001	COX20-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX20-001 ENSP00000406327 ENST00000411948	Q5RI15 [Direct mapping] Cytochrome c oxidase protein 20 homolog B3KM21 [Target identity:100%; Query identity:100%] Family with sequence similarity 36, member A, isoform CRA_a; cDNA FLJ10004 fis, clone HEMBA1000076, highly similar to Protein FAM36A; cDNA FLJ43269 fis, clone KIDNE2000665, highly similar to Protein FAM36A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0009060 [aerobic respiration] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	118 aa 13.3 kDa	No	2
COX20-005 ENSP00000355486 ENST00000366528	Q5RI15 [Direct mapping] Cytochrome c oxidase protein 20 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0009060 [aerobic respiration] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	130 aa 14.7 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.