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Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Paired antibodies with high similarity supports the expression profile.
RNA tissue category: Tissue enhanced (testis, ovary, small intestine)
GENE INFORMATION
Gene name
HSD3B2 (HGNC Symbol)
Synonyms
SDR11E2
Description
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0006694 [steroid biosynthetic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]