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NEU4

GENERAL INFORMATION

Gene name

 NEU4

Gene description

 Sialidase 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (colon, cerebral cortex, duodenum, small intestine, liver, rectum, bone marrow)
GTEx:Tissue enhanced (liver)
FANTOM5:Group enriched (small intestine, liver, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in enteroendocrine cells in the gastrointestinal tract and processes in CNS. Membranous expression in renal glomeruli.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA037394 , HPA037395
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, cerebral cortex, duodenum, small intestine, liver, rectum, bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, liver, colon)

GENE INFORMATION

Gene name

 NEU4

Synonyms

Description

 Sialidase 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241808825 - 241817413

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204099 (version 83.38)

Entrez gene

 129807

UniProt

 Q8WWR8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWR8

Antibodypedia

 NEU4 antibodies

PROTEIN BROWSER
«
NEU4-001
NEU4-002
NEU4-003
NEU4-004
NEU4-007
NEU4-008
NEU4-010
NEU4-011
NEU4-012
NEU4-013
NEU4-014
NEU4-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEU4-001
ENSP00000385149
ENST00000404257
Q8WWR8 [Direct mapping]
Sialidase-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006516 [glycoprotein catabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006689 [ganglioside catabolic process]
GO:0009313 [oligosaccharide catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019866 [organelle inner membrane]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052794 [exo-alpha-(2->3)-sialidase activity]
GO:0052795 [exo-alpha-(2->6)-sialidase activity]
GO:0052796 [exo-alpha-(2->8)-sialidase activity]
Show all
 496 aa
52.9 kDa 		No 0
NEU4-002
ENSP00000375830
ENST00000391969
Q8WWR8 [Direct mapping]
Sialidase-4
B3KR54 [Target identity:100%; Query identity:100%]
Sialidase 4, isoform CRA_b; cDNA FLJ33719 fis, clone BRAWH2009490, highly similar to Sialidase-4 (EC 3.2.1.18); cDNA FLJ54457, highly similar to Sialidase-4 (EC 3.2.1.18)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006516 [glycoprotein catabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006689 [ganglioside catabolic process]
GO:0009313 [oligosaccharide catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019866 [organelle inner membrane]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052794 [exo-alpha-(2->3)-sialidase activity]
GO:0052795 [exo-alpha-(2->6)-sialidase activity]
GO:0052796 [exo-alpha-(2->8)-sialidase activity]
Show all
 484 aa
51.6 kDa 		No 0
NEU4-003
ENSP00000320318
ENST00000325935
Q8WWR8 [Direct mapping]
Sialidase-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006516 [glycoprotein catabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006689 [ganglioside catabolic process]
GO:0009313 [oligosaccharide catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019866 [organelle inner membrane]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052794 [exo-alpha-(2->3)-sialidase activity]
GO:0052795 [exo-alpha-(2->6)-sialidase activity]
GO:0052796 [exo-alpha-(2->8)-sialidase activity]
Show all
 497 aa
53.1 kDa 		No 0
NEU4-004
ENSP00000384804
ENST00000405370
Q8WWR8 [Direct mapping]
Sialidase-4
B3KR54 [Target identity:100%; Query identity:100%]
Sialidase 4, isoform CRA_b; cDNA FLJ33719 fis, clone BRAWH2009490, highly similar to Sialidase-4 (EC 3.2.1.18); cDNA FLJ54457, highly similar to Sialidase-4 (EC 3.2.1.18)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006516 [glycoprotein catabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006689 [ganglioside catabolic process]
GO:0009313 [oligosaccharide catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019866 [organelle inner membrane]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052794 [exo-alpha-(2->3)-sialidase activity]
GO:0052795 [exo-alpha-(2->6)-sialidase activity]
GO:0052796 [exo-alpha-(2->8)-sialidase activity]
Show all
 484 aa
51.6 kDa 		No 0
NEU4-007
ENSP00000385402
ENST00000407683
Q8WWR8 [Direct mapping]
Sialidase-4
B3KR54 [Target identity:100%; Query identity:100%]
Sialidase 4, isoform CRA_b; cDNA FLJ33719 fis, clone BRAWH2009490, highly similar to Sialidase-4 (EC 3.2.1.18); cDNA FLJ54457, highly similar to Sialidase-4 (EC 3.2.1.18)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006516 [glycoprotein catabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006689 [ganglioside catabolic process]
GO:0009313 [oligosaccharide catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019866 [organelle inner membrane]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052794 [exo-alpha-(2->3)-sialidase activity]
GO:0052795 [exo-alpha-(2->6)-sialidase activity]
GO:0052796 [exo-alpha-(2->8)-sialidase activity]
Show all
 484 aa
51.6 kDa 		No 0
NEU4-008
ENSP00000397860
ENST00000423583
C9J5X2 [Direct mapping]
Sialidase-4
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0008152 [metabolic process]
Show all
 188 aa
20.1 kDa 		No 0
NEU4-010
ENSP00000397167
ENST00000415936
C9J2R4 [Direct mapping]
Sialidase-4
Show all
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0008152 [metabolic process]
Show all
 215 aa
22.5 kDa 		No 0
NEU4-011
ENSP00000412688
ENST00000435934
C9J295 [Direct mapping]
Sialidase-4
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
 52 aa
5.4 kDa 		No 0
NEU4-012
ENSP00000398571
ENST00000435894
C9J2V4 [Direct mapping]
Sialidase-4
Show all
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0008152 [metabolic process]
Show all
 77 aa
8.4 kDa 		No 0
NEU4-013
ENSP00000406678
ENST00000426032
C9IZG9 [Direct mapping]
Sialidase-4
Show all
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0008152 [metabolic process]
Show all
 214 aa
22.5 kDa 		No 0
NEU4-014
ENSP00000388707
ENST00000420288
C9JRN9 [Direct mapping]
Sialidase-4
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0008152 [metabolic process]
Show all
 260 aa
27.8 kDa 		No 0
NEU4-017
ENSP00000396197
ENST00000428592
C9JEA3 [Direct mapping]
Sialidase-4
Show all
Predicted intracellular proteins
Show all
GO:0004308 [exo-alpha-sialidase activity]
GO:0008152 [metabolic process]
Show all
 144 aa
15.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.