Expression of PTPN20 in cancer - Summary

CANCER ATLAS

Gene description

Protein tyrosine phosphatase, non-receptor type 20

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA043337	HPA048310

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cancer tissues showed moderate nuclear staining with additonal cytoplasmic positivity in a few cases. Rare cases of stomach, pancreas and urothelial cancers displayed strong positivity.

GENE INFORMATION
Gene name	PTPN20 (HGNC Symbol)
Synonyms	bA142I17.1, bA42B19.1, CT126, DKFZP566K0524, PTPN20A, PTPN20B
Description	Protein tyrosine phosphatase, non-receptor type 20 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	46911396 - 47002488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204179 (version 83.38)
Entrez gene	26095
UniProt	Q4JDL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q4JDL3
Antibodypedia	PTPN20 antibodies

PROTEIN BROWSER

PTPN20-001	PTPN20-002	PTPN20-003	PTPN20-004	PTPN20-005	PTPN20-006	PTPN20-007	PTPN20-008	PTPN20-009	PTPN20-010	PTPN20-011	PTPN20-012	PTPN20-013	PTPN20-014	PTPN20-015	PTPN20-016	PTPN20-017	PTPN20-018	PTPN20-022	PTPN20-024	PTPN20-025	PTPN20-026	PTPN20-027	PTPN20-201	PTPN20-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPN20-001 ENSP00000363459 ENST00000374339	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	420 aa 48.4 kDa	No	0
PTPN20-002 ENSP00000363466 ENST00000374346	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	226 aa 25.9 kDa	No	0
PTPN20-003 ENSP00000425912 ENST00000513156	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	269 aa 30.6 kDa	No	0
PTPN20-004 ENSP00000379077 ENST00000395727	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	228 aa 26.4 kDa	No	0
PTPN20-005 ENSP00000426355 ENST00000505814	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	339 aa 39.2 kDa	No	0
PTPN20-006 ENSP00000424283 ENST00000511769	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	411 aa 47.4 kDa	No	0
PTPN20-007 ENSP00000379071 ENST00000395721	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	339 aa 39.2 kDa	No	0
PTPN20-008 ENSP00000423819 ENST00000509900	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	145 aa 16.6 kDa	No	0
PTPN20-009 ENSP00000421921 ENST00000506080	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	339 aa 39.2 kDa	No	0
PTPN20-010 ENSP00000421404 ENST00000502254	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	145 aa 16.4 kDa	No	0
PTPN20-011 ENSP00000422839 ENST00000513266	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	197 aa 22.4 kDa	No	0
PTPN20-012 ENSP00000425012 ENST00000509599	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	226 aa 25.9 kDa	No	0
PTPN20-013 ENSP00000420995 ENST00000502705	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	206 aa 23.9 kDa	No	0
PTPN20-014 ENSP00000425362 ENST00000509774	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	217 aa 24.9 kDa	No	0
PTPN20-015 ENSP00000424491 ENST00000508602	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	145 aa 16.6 kDa	No	0
PTPN20-016 ENSP00000396009 ENST00000417004	Q5T1G4 [Direct mapping] Protein tyrosine phosphatase, non-receptor type 20A; Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		126 aa 14.5 kDa	No	0
PTPN20-017 ENSP00000422384 ENST00000506881	D6RC68 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		68 aa 7.9 kDa	No	0
PTPN20-018 ENSP00000427676 ENST00000503851	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	136 aa 15.4 kDa	No	0
PTPN20-022 ENSP00000379072 ENST00000395722	Q4JDK3 [Direct mapping] Non-receptor protein tyrosine phosphatase 20 variant 15; Non-receptor protein tyrosine phosphatase 20 variant 16; Non-receptor protein tyrosine phosphatase 20 variant 17; Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		64 aa 7.2 kDa	No	0
PTPN20-024 ENSP00000477675 ENST00000513159	Q4JDK3 [Direct mapping] Non-receptor protein tyrosine phosphatase 20 variant 15; Non-receptor protein tyrosine phosphatase 20 variant 16; Non-receptor protein tyrosine phosphatase 20 variant 17; Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		64 aa 7.2 kDa	No	0
PTPN20-025 ENSP00000479990 ENST00000513756	Q4JDK3 [Direct mapping] Non-receptor protein tyrosine phosphatase 20 variant 15; Non-receptor protein tyrosine phosphatase 20 variant 16; Non-receptor protein tyrosine phosphatase 20 variant 17; Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		64 aa 7.2 kDa	No	0
PTPN20-026 ENSP00000480504 ENST00000508715	Q4JDK3 [Direct mapping] Non-receptor protein tyrosine phosphatase 20 variant 15; Non-receptor protein tyrosine phosphatase 20 variant 16; Non-receptor protein tyrosine phosphatase 20 variant 17; Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		64 aa 7.2 kDa	No	0
PTPN20-027 ENSP00000363462 ENST00000374342	Q4JDK3 [Direct mapping] Non-receptor protein tyrosine phosphatase 20 variant 15; Non-receptor protein tyrosine phosphatase 20 variant 16; Non-receptor protein tyrosine phosphatase 20 variant 17; Tyrosine-protein phosphatase non-receptor type 20 Show all	Predicted intracellular proteins Show all		64 aa 7.2 kDa	No	0
PTPN20-201 ENSP00000363335 ENST00000374218	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	339 aa 39.2 kDa	No	0
PTPN20-202 ENSP00000379075 ENST00000395725	Q4JDL3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	145 aa 16.6 kDa	No	0