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COL5A2

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GENERAL INFORMATION

Gene name

 COL5A2

Gene description

 Collagen, type V, alpha 2

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 COL5A2

Synonyms

Description

 Collagen, type V, alpha 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q32.2

Chromosome location (bp)

 189031896 - 189179879

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204262 (version 83.38)

Entrez gene

 1290

UniProt

 P05997 (UniProt - Evidence at protein level)

neXtProt

 NX_P05997

Antibodypedia

 COL5A2 antibodies

PROTEIN BROWSER
COL5A2-001
COL5A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COL5A2-001
ENSP00000364000
ENST00000374866
P05997 [Direct mapping]
Collagen alpha-2(V) chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0003674 [molecular_function]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005588 [collagen type V trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007411 [axon guidance]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0043588 [skin development]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048592 [eye morphogenesis]
GO:0071230 [cellular response to amino acid stimulus]
GO:1903225 [negative regulation of endodermal cell differentiation]
Show all
 1499 aa
144.9 kDa 		Yes 0
COL5A2-201
ENSP00000482184
ENST00000618828
A0A087WYX9 [Direct mapping]
Collagen alpha-2(V) chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
Show all
 1112 aa
107 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.