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Moderate to strong cytoplasmic immunoreactivity was found in most malignant lymphomas, melanomas and stomach cancers. Positivity was seen in squamous cell carcinomas of skin, while most basal cell carcinomas were negative.
GENE INFORMATION
Gene name
TAP2 (HGNC Symbol)
Synonyms
ABCB3, D6S217E, PSF2, RING11
Description
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]
Q03519 [Direct mapping] Antigen peptide transporter 2 Q5JNW1 [Target identity:100%; Query identity:100%] TAP2; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_b; cDNA FLJ77215, highly similar to Homo sapiens transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), mRNA
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Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0043657 [host cell] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0043657 [host cell] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015197 [peptide transporter activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042287 [MHC protein binding] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0055085 [transmembrane transport]
