Cell atlas - PBX2 - The Human Protein Atlas

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PBX2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PBX2
Gene description	Pre-B-cell leukemia homeobox 2
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA061478
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061478	CACO-2	Nucleoplasm
	HPA061478	MCF7	Nucleoplasm
	HPA061478	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	PBX2 (HGNC Symbol)
Synonyms	G17, HOX12, PBX2MHC
Description	Pre-B-cell leukemia homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	32184741 - 32190186
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204304 (version 83.38)
Entrez gene	5089
UniProt	P40425 (UniProt - Evidence at protein level)
neXtProt	NX_P40425
Antibodypedia	PBX2 antibodies

PROTEIN BROWSER

PBX2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PBX2-001 ENSP00000364190 ENST00000375050	P40425 [Direct mapping] Pre-B-cell leukemia transcription factor 2 A0A024RCR3 [Target identity:100%; Query identity:100%] HCG2039588 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0009954 [proximal/distal pattern formation] GO:0030326 [embryonic limb morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	430 aa 45.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.