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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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AGER
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AGER

Gene description

Advanced glycosylation end product-specific receptor

Protein class

Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (lung)
GTEx:Tissue enriched (lung)
FANTOM5:Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in pneumocytes and endothelial cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
CAB011682
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)

GENE INFORMATION

Gene name

AGER (HGNC Symbol)

Synonyms

RAGE

Description

Advanced glycosylation end product-specific receptor (HGNC Symbol)

Entrez gene summary

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32180968 - 32184324

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204305 (version 83.38)

Entrez gene

177

UniProt

Q15109 (UniProt - Evidence at protein level)

neXtProt

NX_Q15109

Antibodypedia

AGER antibodies

PROTEIN BROWSER

«
AGER-001
AGER-002
AGER-004
AGER-007
AGER-008
AGER-201
AGER-202
AGER-203
AGER-204
AGER-205
AGER-206
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGER-001
ENSP00000364217
ENST00000375076
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
404 aa
42.8 kDa
Yes 1
AGER-002
ENSP00000364195
ENST00000375055
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
347 aa
37 kDa
Yes 0
AGER-004
ENSP00000364208
ENST00000375067
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
342 aa
36.2 kDa
Yes 0
AGER-007
ENSP00000364196
ENST00000375056
Q5SSZ2 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
233 aa
25.2 kDa
Yes 0
AGER-008
ENSP00000398466
ENST00000450110
Q5SSZ3 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
234 aa
25.2 kDa
Yes 0
AGER-201
ENSP00000364206
ENST00000375065
C0IP14 [Direct mapping]
Advanced glycosylation end product-specific receptor; Advanced glycosylation end product-specific receptor variant CC
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
133 aa
13.8 kDa
No 1
AGER-202
ENSP00000364210
ENST00000375069
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007420 [brain development]
GO:0008201 [heparin binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009611 [response to wounding]
GO:0009750 [response to fructose]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014002 [astrocyte development]
GO:0014823 [response to activity]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0031175 [neuron projection development]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0033189 [response to vitamin A]
GO:0033595 [response to genistein]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0035690 [cellular response to drug]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050785 [advanced glycation end-product receptor activity]
GO:0050930 [induction of positive chemotaxis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051101 [regulation of DNA binding]
GO:0051595 [response to methylglyoxal]
GO:0055074 [calcium ion homeostasis]
GO:0055093 [response to hyperoxia]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0060290 [transdifferentiation]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070379 [high mobility group box 1 binding]
GO:0071333 [cellular response to glucose stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0072657 [protein localization to membrane]
GO:0072714 [response to selenite ion]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1901216 [positive regulation of neuron death]
GO:1904597 [negative regulation of connective tissue replacement involved in inflammatory response wound healing]
GO:1904599 [advanced glycation end-product binding]
GO:1904604 [negative regulation of advanced glycation end-product receptor activity]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000676 [positive regulation of type B pancreatic cell apoptotic process]
Show all
420 aa
44.8 kDa
Yes 1
AGER-203
ENSP00000364211
ENST00000375070
A8MS87 [Direct mapping]
Advanced glycosylation end product-specific receptor; Advanced glycosylation end product-specific receptor variant BB
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
294 aa
31.3 kDa
No 1
AGER-204
ENSP00000387887
ENST00000438221
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
363 aa
39 kDa
Yes 0
AGER-205
ENSP00000445389
ENST00000538695
B5A982 [Direct mapping]
Advanced glycosylation end product-specific receptor; Advanced glycosylation end products transcript variant; Soluble RAGE variant 5
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
128 aa
14 kDa
Yes 0
AGER-206
ENSP00000484081
ENST00000620802
Q3L1R2 [Direct mapping]
Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end-products deletion exon3-10 variant
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
153 aa
16.3 kDa
Yes 1

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