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DXO

GENERAL INFORMATION

Gene name

 DXO

Gene description

 Decapping exoribonuclease

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA046708
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DXO (HGNC Symbol)

Synonyms

 DOM3Z

Description

 Decapping exoribonuclease (HGNC Symbol)

Entrez gene summary

 This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31969810 - 31972292

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204348 (version 83.38)

Entrez gene

 1797

UniProt

 O77932 (UniProt - Evidence at transcript level)

neXtProt

 NX_O77932

Antibodypedia

 DXO antibodies

PROTEIN BROWSER
DXO-001
DXO-006
DXO-007
DXO-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DXO-001
ENSP00000337759
ENST00000337523
O77932 [Direct mapping]
Decapping and exoribonuclease protein
A0A024RCW8 [Target identity:100%; Query identity:100%]
Dom-3 homolog Z (C. elegans), isoform CRA_a
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0003729 [mRNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006402 [mRNA catabolic process]
GO:0008152 [metabolic process]
GO:0008409 [5'-3' exonuclease activity]
GO:0034353 [RNA pyrophosphohydrolase activity]
GO:0050779 [RNA destabilization]
GO:0071028 [nuclear mRNA surveillance]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 396 aa
44.9 kDa 		No 0
DXO-006
ENSP00000364498
ENST00000375349
O77932 [Direct mapping]
Decapping and exoribonuclease protein
A0A024RCW8 [Target identity:100%; Query identity:100%]
Dom-3 homolog Z (C. elegans), isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0003729 [mRNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006402 [mRNA catabolic process]
GO:0008152 [metabolic process]
GO:0008409 [5'-3' exonuclease activity]
GO:0034353 [RNA pyrophosphohydrolase activity]
GO:0050779 [RNA destabilization]
GO:0071028 [nuclear mRNA surveillance]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 396 aa
44.9 kDa 		No 0
DXO-007
ENSP00000364505
ENST00000375356
O77932 [Direct mapping]
Decapping and exoribonuclease protein
A0A024RCW8 [Target identity:100%; Query identity:100%]
Dom-3 homolog Z (C. elegans), isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0003729 [mRNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006402 [mRNA catabolic process]
GO:0008152 [metabolic process]
GO:0008409 [5'-3' exonuclease activity]
GO:0034353 [RNA pyrophosphohydrolase activity]
GO:0050779 [RNA destabilization]
GO:0071028 [nuclear mRNA surveillance]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 396 aa
44.9 kDa 		No 0
DXO-014
ENSP00000419588
ENST00000495340
H7C5D2 [Direct mapping]
Decapping and exoribonuclease protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 174 aa
19.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.