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Cancer tissues displayed moderate to strong nuclear immunoreactivity. Additional cytoplasmic and membranous staining was observed in several malignant melanomas, colorectal, endometrial and pancreatic cancers.
GENE INFORMATION
Gene name
ZBTB12 (HGNC Symbol)
Synonyms
C6orf46, D6S59E, G10, NG35
Description
Zinc finger and BTB domain containing 12 (HGNC Symbol)
Q9Y330 [Direct mapping] Zinc finger and BTB domain-containing protein 12
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0046872 [metal ion binding]