Fields »
ABOUT
HELP
BLOG
EHMT2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 EHMT2

Gene description

 Euchromatic histone-lysine N-methyltransferase 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (supported)

Additional location

 In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA060259
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the nucleoplasm.

Main location

 Nuclear speckles (supported)

Additional location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA060259 HEK 293 Nucleoplasm
Nuclear speckles
HPA060259 MCF7 Nucleoplasm
Nuclear speckles
HPA060259 U-2 OS Nuclear speckles

GENE INFORMATION

Gene name

 EHMT2 (HGNC Symbol)

Synonyms

 BAT8, C6orf30, Em:AF134726.3, G9A, KMT1C, NG36/G9a

Description

 Euchromatic histone-lysine N-methyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31879759 - 31897687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204371 (version 83.38)

Entrez gene

 10919

UniProt

 Q96KQ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96KQ7

Antibodypedia

 EHMT2 antibodies

PROTEIN BROWSER
EHMT2-001
EHMT2-007
EHMT2-008
EHMT2-009
EHMT2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EHMT2-001
ENSP00000364687
ENST00000375537
Q96KQ7 [Direct mapping]
Histone-lysine N-methyltransferase EHMT2
A0A024RCN9 [Target identity:100%; Query identity:100%]
Euchromatic histone-lysine N-methyltransferase 2, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006275 [regulation of DNA replication]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0008270 [zinc ion binding]
GO:0016279 [protein-lysine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0018027 [peptidyl-lysine dimethylation]
GO:0034968 [histone lysine methylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046974 [histone methyltransferase activity (H3-K9 specific)]
GO:0046976 [histone methyltransferase activity (H3-K27 specific)]
GO:0051567 [histone H3-K9 methylation]
GO:0070734 [histone H3-K27 methylation]
GO:0070742 [C2H2 zinc finger domain binding]
Show all
 1210 aa
132.4 kDa 		Yes 0
EHMT2-007
ENSP00000364680
ENST00000375530
Q96KQ7 [Direct mapping]
Histone-lysine N-methyltransferase EHMT2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006275 [regulation of DNA replication]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0008270 [zinc ion binding]
GO:0016279 [protein-lysine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0018027 [peptidyl-lysine dimethylation]
GO:0034968 [histone lysine methylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046974 [histone methyltransferase activity (H3-K9 specific)]
GO:0046976 [histone methyltransferase activity (H3-K27 specific)]
GO:0051567 [histone H3-K9 methylation]
GO:0070734 [histone H3-K27 methylation]
GO:0070742 [C2H2 zinc finger domain binding]
Show all
 1176 aa
129 kDa 		Yes 0
EHMT2-008
ENSP00000379078
ENST00000395728
A2ABF9 [Direct mapping]
Histone-lysine N-methyltransferase EHMT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0008270 [zinc ion binding]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0034968 [histone lysine methylation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 1267 aa
138.8 kDa 		No 0
EHMT2-009
ENSP00000364678
ENST00000375528
A2ABF8 [Direct mapping]
Histone-lysine N-methyltransferase EHMT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006306 [DNA methylation]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007130 [synaptonemal complex assembly]
GO:0007281 [germ cell development]
GO:0007286 [spermatid development]
GO:0007616 [long-term memory]
GO:0008270 [zinc ion binding]
GO:0009566 [fertilization]
GO:0010424 [DNA methylation on cytosine within a CG sequence]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0031667 [response to nutrient levels]
GO:0034968 [histone lysine methylation]
GO:0035265 [organ growth]
GO:0035690 [cellular response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044030 [regulation of DNA methylation]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045471 [response to ethanol]
GO:0046974 [histone methyltransferase activity (H3-K9 specific)]
GO:0046976 [histone methyltransferase activity (H3-K27 specific)]
GO:0051567 [histone H3-K9 methylation]
GO:0051569 [regulation of histone H3-K4 methylation]
GO:0051570 [regulation of histone H3-K9 methylation]
GO:0060992 [response to fungicide]
GO:0070734 [histone H3-K27 methylation]
Show all
 1233 aa
135.4 kDa 		No 0
EHMT2-012
ENSP00000412353
ENST00000436026
H0Y4K5 [Direct mapping]
Histone-lysine N-methyltransferase EHMT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 298 aa
32.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.