Expression of HSPA1L in cancer - Summary

CANCER ATLAS

Gene description

Heat shock 70kDa protein 1-like

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043285	HPA052504

GENE INFORMATION
Gene name	HSPA1L (HGNC Symbol)
Synonyms	HSP70-HOM, hum70t
Description	Heat shock 70kDa protein 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31809619 - 31815065
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204390 (version 83.38)
Entrez gene	3305
UniProt	P34931 (UniProt - Evidence at protein level)
neXtProt	NX_P34931
Antibodypedia	HSPA1L antibodies

PROTEIN BROWSER

HSPA1L-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSPA1L-001 ENSP00000364805 ENST00000375654	P34931 [Direct mapping] Heat shock 70 kDa protein 1-like Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002199 [zona pellucida receptor complex] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006986 [response to unfolded protein] GO:0007339 [binding of sperm to zona pellucida] GO:0008180 [COP9 signalosome] GO:0031072 [heat shock protein binding] GO:0031625 [ubiquitin protein ligase binding] GO:0034605 [cellular response to heat] GO:0042026 [protein refolding] GO:0044297 [cell body] GO:0051082 [unfolded protein binding] GO:0072562 [blood microparticle] GO:1900034 [regulation of cellular response to heat] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	641 aa 70.4 kDa	No	0