Tissue expression of C6orf25 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C6orf25
Gene description	Chromosome 6 open reading frame 25
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enhanced (skin, spleen)
FANTOM5:	Tissue enriched (spleen)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (spleen)

GENE INFORMATION
Gene name	C6orf25 (HGNC Symbol)
Synonyms	G6b, NG31
Description	Chromosome 6 open reading frame 25 (HGNC Symbol)
Entrez gene summary	This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31718594 - 31726714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204420 (version 83.38)
Entrez gene	80739
UniProt	O95866 (UniProt - Evidence at protein level)
neXtProt	NX_O95866
Antibodypedia	C6orf25 antibodies

PROTEIN BROWSER

C6orf25-001	C6orf25-002	C6orf25-003	C6orf25-004	C6orf25-005	C6orf25-007	C6orf25-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C6orf25-001 ENSP00000364967 ENST00000375809	O95866 [Direct mapping] Protein G6b B0V023 [Target identity:100%; Query identity:100%] Chromosome 6 open reading frame 25, isoform CRA_h; cDNA FLJ35073 fis, clone PLACE6000630 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] Show all	237 aa 25 kDa	Yes	1
C6orf25-002 ENSP00000364964 ENST00000375806	O95866 [Direct mapping] Protein G6b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] GO:0030220 [platelet formation] GO:0035855 [megakaryocyte development] Show all	241 aa 26.2 kDa	Yes	1
C6orf25-003 ENSP00000364963 ENST00000375805	O95866 [Direct mapping] Protein G6b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] Show all	217 aa 23.6 kDa	Yes	0
C6orf25-004 ENSP00000364962 ENST00000375804	O95866 [Direct mapping] Protein G6b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] Show all	193 aa 20.2 kDa	Yes	0
C6orf25-005 ENSP00000364972 ENST00000375814	O95866 [Direct mapping] Protein G6b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] Show all	197 aa 21.3 kDa	Yes	0
C6orf25-007 ENSP00000364968 ENST00000375810	O95866 [Direct mapping] Protein G6b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] Show all	222 aa 23.6 kDa	Yes	1
C6orf25-009 ENSP00000419306 ENST00000480039	B7ZLJ5 [Direct mapping] C6orf25 protein; Protein G6b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	220 aa 24 kDa	Yes	1