Tissue expression of MICB - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MICB
Gene description	MHC class I polypeptide-related sequence B
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enhanced (vagina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (vagina)

GENE INFORMATION
Gene name	MICB (HGNC Symbol)
Synonyms	PERB11.2
Description	MHC class I polypeptide-related sequence B (HGNC Symbol)
Entrez gene summary	This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31494881 - 31511124
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204516 (version 83.38)
Entrez gene	4277
UniProt	Q29980 (UniProt - Evidence at protein level)
neXtProt	NX_Q29980
Antibodypedia	MICB antibodies

PROTEIN BROWSER

MICB-001	MICB-002	MICB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MICB-001 ENSP00000252229 ENST00000252229	X6R344 [Direct mapping] MHC class I polypeptide-related sequence B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] Show all	383 aa 42.6 kDa	Yes	1
MICB-002 ENSP00000382103 ENST00000399150	Q29980 [Direct mapping] MHC class I polypeptide-related sequence B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001913 [T cell mediated cytotoxicity] GO:0002429 [immune response-activating cell surface receptor signaling pathway] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0006979 [response to oxidative stress] GO:0009408 [response to heat] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019835 [cytolysis] GO:0032526 [response to retinoic acid] GO:0042267 [natural killer cell mediated cytotoxicity] GO:0046629 [gamma-delta T cell activation] GO:0046703 [natural killer cell lectin-like receptor binding] GO:0050689 [negative regulation of defense response to virus by host] GO:0050776 [regulation of immune response] Show all	340 aa 37.6 kDa	Yes	1
MICB-201 ENSP00000442345 ENST00000538442	F5H7Q8 [Direct mapping] MHC class I polypeptide-related sequence B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] Show all	351 aa 39.2 kDa	No	1