Tissue expression of LILRB3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LILRB3
Gene description	Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (appendix, spleen, lung, bone marrow, urinary bladder, adipose tissue)
GTEx:	Group enriched (spleen, lung)
FANTOM5:	Tissue enhanced (spleen, lymph node)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, spleen, lung, bone marrow, urinary bladder, adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, lymph node)

GENE INFORMATION
Gene name	LILRB3 (HGNC Symbol)
Synonyms	CD85a, HL9, ILT5, LIR-3, LIR3
Description	Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54216278 - 54223506
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000204577 (version 83.38)
Entrez gene	11025
UniProt	O75022 (UniProt - Evidence at transcript level)
neXtProt	NX_O75022
Antibodypedia	LILRB3 antibodies

PROTEIN BROWSER

LILRB3-001	LILRB3-005	LILRB3-008	LILRB3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LILRB3-001 ENSP00000375630 ENST00000391750	O75022 [Direct mapping] Leukocyte immunoglobulin-like receptor subfamily B member 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0045671 [negative regulation of osteoclast differentiation] Show all	631 aa 69.4 kDa	Yes	1
LILRB3-005 ENSP00000388199 ENST00000445347	C9JWL8 [Direct mapping] Leukocyte immunoglobulin-like receptor subfamily B member 3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	158 aa 17.4 kDa	Yes	0
LILRB3-008 ENSP00000345184 ENST00000346401	F8W6G6 [Direct mapping] Leukocyte immunoglobulin-like receptor subfamily B member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	643 aa 70.6 kDa	Yes	1
LILRB3-009 ENSP00000245620 ENST00000245620	O75022 [Direct mapping] Leukocyte immunoglobulin-like receptor subfamily B member 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0045671 [negative regulation of osteoclast differentiation] Show all	632 aa 69.6 kDa	Yes	1