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DDR1

CANCER ATLAS

Gene description

 Discoidin domain receptor tyrosine kinase 1

Protein class

 CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB010162
CAB025656

GENE INFORMATION

Gene name

 DDR1 (HGNC Symbol)

Synonyms

 CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6

Description

 Discoidin domain receptor tyrosine kinase 1 (HGNC Symbol)

Entrez gene summary

 Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30876421 - 30900156

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204580 (version 83.38)

Entrez gene

 780

UniProt

 Q08345 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08345

Antibodypedia

 DDR1 antibodies

PROTEIN BROWSER
«
DDR1-001
DDR1-002
DDR1-003
DDR1-005
DDR1-006
DDR1-007
DDR1-009
DDR1-010
DDR1-012
DDR1-013
DDR1-014
DDR1-015
DDR1-016
DDR1-018
DDR1-020
DDR1-022
DDR1-023
DDR1-024
DDR1-025
DDR1-026
DDR1-027
DDR1-028
DDR1-030
DDR1-031
DDR1-032
DDR1-034
DDR1-035
DDR1-036
DDR1-037
DDR1-038
DDR1-039
DDR1-040
DDR1-041
DDR1-044
DDR1-047
DDR1-048
DDR1-049
DDR1-050
DDR1-051
DDR1-205
DDR1-206
DDR1-207
DDR1-208
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDR1-001
ENSP00000406091
ENST00000454612
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCQ1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_d
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 876 aa
97.2 kDa 		Yes 2
DDR1-002
ENSP00000365752
ENST00000376568
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCL1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 913 aa
101.1 kDa 		Yes 2
DDR1-003
ENSP00000365753
ENST00000376569
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCQ1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_d
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 876 aa
97.2 kDa 		Yes 2
DDR1-005
ENSP00000318217
ENST00000324771
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCL1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 913 aa
101.1 kDa 		Yes 2
DDR1-006
ENSP00000365751
ENST00000376567
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCQ1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_d
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 876 aa
97.2 kDa 		Yes 2
DDR1-007
ENSP00000398682
ENST00000417521
A2ABM8 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
Show all
 493 aa
53.8 kDa 		No 1
DDR1-009
ENSP00000424003
ENST00000484556
H0Y9F4 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
Show all
 277 aa
30.8 kDa 		No 0
DDR1-010
ENSP00000426420
ENST00000460944
E7EPH4 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 286 aa
31.9 kDa 		Yes 0
DDR1-012
ENSP00000407699
ENST00000418800
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCQ1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_d
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 876 aa
97.2 kDa 		Yes 2
DDR1-013
ENSP00000379631
ENST00000396342
A2ABL0 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 147 aa
16.2 kDa 		Yes 0
DDR1-014
ENSP00000390593
ENST00000428153
E7EQ30 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 267 aa
29.6 kDa 		Yes 0
DDR1-015
ENSP00000422974
ENST00000503670
D6R9C4 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 41 aa
4.4 kDa 		Yes 0
DDR1-016
ENSP00000409682
ENST00000421124
A2ABL2 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 209 aa
23.2 kDa 		Yes 0
DDR1-018
ENSP00000427552
ENST00000513240
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCJ0 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007566 [embryo implantation]
GO:0007595 [lactation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030198 [extracellular matrix organization]
GO:0031100 [organ regeneration]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0043583 [ear development]
GO:0043588 [skin development]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060749 [mammary gland alveolus development]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 919 aa
101.8 kDa 		Yes 1
DDR1-020
ENSP00000422442
ENST00000508312
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 894 aa
99.1 kDa 		Yes 2
DDR1-022
ENSP00000421189
ENST00000505066
E7EVW6 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 132 aa
14.5 kDa 		Yes 0
DDR1-023
ENSP00000424346
ENST00000502955
D6RB82 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 55 aa
5.8 kDa 		Yes 0
DDR1-024
ENSP00000420833
ENST00000505534
E7EN94 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 101 aa
10.8 kDa 		Yes 0
DDR1-025
ENSP00000424468
ENST00000503180
D6RB35 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.4 kDa 		Yes 0
DDR1-026
ENSP00000423906
ENST00000504679
E7ETX3 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 122 aa
13.2 kDa 		Yes 0
DDR1-027
ENSP00000423749
ENST00000503495
E7EUP7 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 196 aa
21.5 kDa 		Yes 0
DDR1-028
ENSP00000427369
ENST00000508317
E7EUD5 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 127 aa
13.8 kDa 		Yes 0
DDR1-030
ENSP00000422331
ENST00000509639
E7ES06 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 115 aa
12.2 kDa 		Yes 0
DDR1-031
ENSP00000392413
ENST00000412274
D6RBU7 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 58 aa
6.1 kDa 		Yes 0
DDR1-032
ENSP00000424703
ENST00000507901
E7EXB0 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
8.1 kDa 		Yes 0
DDR1-034
ENSP00000425713
ENST00000507046
E7EQ23 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 70 aa
7.4 kDa 		Yes 0
DDR1-035
ENSP00000425113
ENST00000511510
E7ESR9 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 143 aa
15.8 kDa 		Yes 0
DDR1-036
ENSP00000394273
ENST00000437124
E7ERI6 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 153 aa
16.9 kDa 		Yes 0
DDR1-037
ENSP00000424758
ENST00000504651
E7EX99 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 73 aa
7.7 kDa 		Yes 0
DDR1-038
ENSP00000423928
ENST00000513043
D6RB35 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.4 kDa 		Yes 0
DDR1-039
ENSP00000426229
ENST00000512694
E7EPN2 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 170 aa
18.8 kDa 		Yes 0
DDR1-040
ENSP00000422467
ENST00000515233
E7ERN0 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 138 aa
15.3 kDa 		Yes 0
DDR1-041
ENSP00000423492
ENST00000515881
E7ENJ2 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 85 aa
9 kDa 		Yes 0
DDR1-044
ENSP00000421152
ENST00000515219
D6RGW5 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.8 kDa 		No 0
DDR1-047
ENSP00000427597
ENST00000504927
E7ETI3 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 160 aa
17.6 kDa 		Yes 0
DDR1-048
ENSP00000421719
ENST00000512336
E7EVT1 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 112 aa
11.9 kDa 		Yes 0
DDR1-049
ENSP00000422108
ENST00000512725
E7ERN0 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 138 aa
15.3 kDa 		Yes 0
DDR1-050
ENSP00000409400
ENST00000424544
H0Y717 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 196 aa
21.8 kDa 		Yes 0
DDR1-051
ENSP00000427124
ENST00000514434
H0YAH6 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
Show all
 172 aa
18.5 kDa 		No 0
DDR1-205
ENSP00000365754
ENST00000376570
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCQ1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_d
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 876 aa
97.2 kDa 		Yes 2
DDR1-206
ENSP00000365759
ENST00000376575
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 243 aa
27.1 kDa 		Yes 0
DDR1-207
ENSP00000405998
ENST00000446312
A0A0A0MSX3 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 767 aa
85.5 kDa 		Yes 1
DDR1-208
ENSP00000405039
ENST00000452441
Q08345 [Direct mapping]
Epithelial discoidin domain-containing receptor 1
A0A024RCL1 [Target identity:100%; Query identity:100%]
Discoidin domain receptor family, member 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0014909 [smooth muscle cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0038062 [protein tyrosine kinase collagen receptor activity]
GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0043235 [receptor complex]
GO:0044319 [wound healing, spreading of cells]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0061302 [smooth muscle cell-matrix adhesion]
GO:0070062 [extracellular exosome]
Show all
 913 aa
101.1 kDa 		Yes 2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.