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RNA cell line category: Cell line enhanced (A-431, HEK 293, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
HLA-F
Synonyms
Description
Major histocompatibility complex, class I, F (HGNC Symbol)
Entrez gene summary
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0005102 [receptor binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F Q5JZ48 [Target identity:100%; Query identity:100%] Major histocompatibility complex, class I, F
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
