Tissue expression of MOG - Summary - The Human Protein Atlas

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MOG

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MOG
Gene description	Myelin oligodendrocyte glycoprotein
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex)
FANTOM5:	Group enriched (brain, hippocampus, caudate, cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in oligodendrocytes in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA021873
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, hippocampus, caudate, cerebellum)

GENE INFORMATION
Gene name	MOG (HGNC Symbol)
Synonyms	BTN6, BTNL11
Description	Myelin oligodendrocyte glycoprotein (HGNC Symbol)
Entrez gene summary	The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.1
Chromosome location (bp)	29656981 - 29672372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204655 (version 83.38)
Entrez gene	4340
UniProt	Q16653 (UniProt - Evidence at protein level)
neXtProt	NX_Q16653
Antibodypedia	MOG antibodies

PROTEIN BROWSER

MOG-001	MOG-002	MOG-003	MOG-004	MOG-005	MOG-006	MOG-007	MOG-008	MOG-009	MOG-015	MOG-016	MOG-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOG-001 ENSP00000366115 ENST00000376917	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	247 aa 28.2 kDa	Yes	2
MOG-002 ENSP00000366091 ENST00000376894	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	295 aa 33.5 kDa	Yes	2
MOG-003 ENSP00000366085 ENST00000376888	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	131 aa 15 kDa	Yes	2
MOG-004 ENSP00000379929 ENST00000396701	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	213 aa 24.1 kDa	Yes	1
MOG-005 ENSP00000366095 ENST00000376898	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0007568 [aging] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0033993 [response to lipid] GO:0043209 [myelin sheath] GO:0045121 [membrane raft] GO:0046718 [viral entry into host cell] GO:0051593 [response to folic acid] Show all	252 aa 28.6 kDa	Yes	2
MOG-006 ENSP00000417405 ENST00000494692	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	229 aa 25.8 kDa	Yes	1
MOG-007 ENSP00000379932 ENST00000396704	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	224 aa 25.4 kDa	Yes	1
MOG-008 ENSP00000366088 ENST00000376891	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	206 aa 23.2 kDa	Yes	1
MOG-009 ENSP00000410866 ENST00000431798	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	208 aa 23.6 kDa	Yes	1
MOG-015 ENSP00000418090 ENST00000483013	E9PG44 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	92 aa 10.4 kDa	Yes	1
MOG-016 ENSP00000420350 ENST00000490427	Q16653 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0016021 [integral component of membrane] GO:0046718 [viral entry into host cell] Show all	108 aa 12.1 kDa	Yes	1
MOG-017 ENSP00000409394 ENST00000416766	C9JTE0 [Direct mapping] Myelin-oligodendrocyte glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	209 aa 23.9 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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