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A majority of cancer tissues showed weak to moderate cytoplasmic and nuclear positivity. Few cases of testicular, liver, breast, colorectal and stomach cancers exhibited strong immunoreactivity.
GENE INFORMATION
Gene name
TRIM27 (HGNC Symbol)
Synonyms
RFP, RNF76
Description
Tripartite motif containing 27 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002820 [negative regulation of adaptive immune response] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006469 [negative regulation of protein kinase activity] GO:0007283 [spermatogenesis] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016605 [PML body] GO:0016874 [ligase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030904 [retromer complex] GO:0031965 [nuclear membrane] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032897 [negative regulation of viral transcription] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0042147 [retrograde transport, endosome to Golgi] GO:0045087 [innate immune response] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046872 [metal ion binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051127 [positive regulation of actin nucleation] GO:0070206 [protein trimerization] GO:0070534 [protein K63-linked ubiquitination] GO:0072643 [interferon-gamma secretion] GO:0090281 [negative regulation of calcium ion import] GO:1900041 [negative regulation of interleukin-2 secretion] GO:1902187 [negative regulation of viral release from host cell]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002820 [negative regulation of adaptive immune response] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006469 [negative regulation of protein kinase activity] GO:0007283 [spermatogenesis] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016605 [PML body] GO:0016874 [ligase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030904 [retromer complex] GO:0031965 [nuclear membrane] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032897 [negative regulation of viral transcription] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0042147 [retrograde transport, endosome to Golgi] GO:0045087 [innate immune response] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046872 [metal ion binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0070206 [protein trimerization] GO:0070534 [protein K63-linked ubiquitination] GO:0072643 [interferon-gamma secretion] GO:0090281 [negative regulation of calcium ion import] GO:1900041 [negative regulation of interleukin-2 secretion]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)