Cell atlas - RANBP17 - The Human Protein Atlas

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RANBP17

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nuclear membrane

Human cell
	Cytosol
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RANBP17
Gene description	RAN binding protein 17
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the nuclear membrane & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Nuclear membrane (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA029568
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the nuclear membrane & cytosol.

Main location

Nuclear bodies (approved)

Additional location

Nuclear membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029568	HEK 293	Nuclear membrane	Spatial
	HPA029568	HEK 293	Nuclear bodies	Spatial
	HPA029568	RH-30	Nuclear bodies
	HPA029568	U-2 OS	Nuclear membrane
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	RANBP17
Synonyms
Description	RAN binding protein 17 (HGNC Symbol)
Entrez gene summary	The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	170861870 - 171300015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204764 (version 83.38)
Entrez gene	64901
UniProt	Q9H2T7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2T7
Antibodypedia	RANBP17 antibodies

PROTEIN BROWSER

RANBP17-001	RANBP17-011	RANBP17-012	RANBP17-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RANBP17-001 ENSP00000427975 ENST00000523189	Q9H2T7 [Direct mapping] Ran-binding protein 17 Q546R4 [Target identity:100%; Query identity:100%] RAN binding protein 17, isoform CRA_b Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005049 [nuclear export signal receptor activity] GO:0005488 [binding] GO:0005525 [GTP binding] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0006611 [protein export from nucleus] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] GO:0051028 [mRNA transport] Show all	1088 aa 124.4 kDa	No	1
RANBP17-011 ENSP00000429609 ENST00000519944	E5RHX1 [Direct mapping] Ran-binding protein 17 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.4 kDa	No	0
RANBP17-012 ENSP00000430577 ENST00000522734	H0YBY7 [Direct mapping] Ran-binding protein 17 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	175 aa 19.8 kDa	No	0
RANBP17-201 ENSP00000478243 ENST00000616486	A0A087WTZ2 [Direct mapping] Ran-binding protein 17 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	518 aa 59.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.