Cell atlas - TCTN1 - The Human Protein Atlas

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TCTN1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Nucleoplasm

Human cell
	Actin Filaments
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TCTN1
Gene description	Tectonic family member 1
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the actin filaments & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Actin filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040036
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the actin filaments & nucleoplasm.

Main location

Nucleoplasm (approved), Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040036	A-431	Nucleoplasm
	HPA040036	A-431	Actin filaments
	HPA040036	U-2 OS	Nucleoplasm
	HPA040036	U-2 OS	Actin filaments

GENE INFORMATION
Gene name	TCTN1 (HGNC Symbol)
Synonyms	FLJ21127, JBTS13, TECT1
Description	Tectonic family member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	110614027 - 110649430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204852 (version 83.38)
Entrez gene	79600
UniProt	Q2MV58 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2MV58
Antibodypedia	TCTN1 antibodies

PROTEIN BROWSER

TCTN1-001	TCTN1-009	TCTN1-019	TCTN1-021	TCTN1-024	TCTN1-032	TCTN1-201	TCTN1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCTN1-001 ENSP00000448735 ENST00000551590	Q2MV58 [Direct mapping] Tectonic-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006996 [organelle organization] GO:0036038 [TCTN-B9D complex] GO:0060271 [cilium morphogenesis] Show all	587 aa 63.6 kDa	Yes	0
TCTN1-009 ENSP00000380779 ENST00000397659	Q2MV58 [Direct mapping] Tectonic-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0001841 [neural tube formation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006996 [organelle organization] GO:0008589 [regulation of smoothened signaling pathway] GO:0016020 [membrane] GO:0021523 [somatic motor neuron differentiation] GO:0021537 [telencephalon development] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021956 [central nervous system interneuron axonogenesis] GO:0035869 [ciliary transition zone] GO:0036038 [TCTN-B9D complex] GO:0060271 [cilium morphogenesis] Show all	592 aa 64.2 kDa	Yes	0
TCTN1-019 ENSP00000380775 ENST00000397655	Q2MV58 [Direct mapping] Tectonic-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006996 [organelle organization] GO:0036038 [TCTN-B9D complex] GO:0060271 [cilium morphogenesis] Show all	573 aa 61.9 kDa	Yes	0
TCTN1-021 ENSP00000473789 ENST00000550703	B4DIB9 [Direct mapping] Tectonic-1; cDNA FLJ55161, highly similar to Tectonic-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		245 aa 26.4 kDa	Yes	0
TCTN1-024 ENSP00000473903 ENST00000471804	S4R339 [Direct mapping] Tectonic-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		162 aa 17 kDa	Yes	0
TCTN1-032 ENSP00000450154 ENST00000549123	F8VQ12 [Direct mapping] Tectonic-1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		73 aa 8.6 kDa	Yes	0
TCTN1-201 ENSP00000366882 ENST00000377654	A0A0A0MRU7 [Direct mapping] Tectonic-1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Show all		483 aa 52.8 kDa	Yes	0
TCTN1-202 ENSP00000484255 ENST00000614115	A0A087X1J4 [Direct mapping] Tectonic-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		573 aa 62 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.