Expression of UQCC3 in cancer - Summary

CANCER ATLAS

Gene description

Ubiquinol-cytochrome c reductase complex assembly factor 3

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046851

GENE INFORMATION
Gene name	UQCC3 (HGNC Symbol)
Synonyms	C11orf83, UNQ655
Description	Ubiquinol-cytochrome c reductase complex assembly factor 3 (HGNC Symbol)
Entrez gene summary	Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62670273 - 62673687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204922 (version 83.38)
Entrez gene	790955
UniProt	Q6UW78 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UW78
Antibodypedia	UQCC3 antibodies

PROTEIN BROWSER

UQCC3-001	UQCC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UQCC3-001 ENSP00000432692 ENST00000531323	Q6UW78 [Direct mapping] Ubiquinol-cytochrome-c reductase complex assembly factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005750 [mitochondrial respiratory chain complex III] GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c] GO:0006754 [ATP biosynthetic process] GO:0031305 [integral component of mitochondrial inner membrane] GO:0034551 [mitochondrial respiratory chain complex III assembly] GO:0042407 [cristae formation] GO:0070300 [phosphatidic acid binding] GO:0097033 [mitochondrial respiratory chain complex III biogenesis] GO:1901612 [cardiolipin binding] Show all	93 aa 10.1 kDa	No	1
UQCC3-201 ENSP00000367189 ENST00000377953	Q6UW78 [Direct mapping] Ubiquinol-cytochrome-c reductase complex assembly factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005750 [mitochondrial respiratory chain complex III] GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c] GO:0006754 [ATP biosynthetic process] GO:0031305 [integral component of mitochondrial inner membrane] GO:0034551 [mitochondrial respiratory chain complex III assembly] GO:0042407 [cristae formation] GO:0070300 [phosphatidic acid binding] GO:0097033 [mitochondrial respiratory chain complex III biogenesis] GO:1901612 [cardiolipin binding] Show all	93 aa 10.1 kDa	No	1