Fields »
ABOUT
HELP
BLOG
CD177

GENERAL INFORMATION

Gene name

 CD177

Gene description

 CD177 molecule

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (bone marrow, rectum, colon, prostate)
GTEx:Group enriched (spleen, colon, prostate, lung)
FANTOM5:Group enriched (spleen, vagina, lymph node, heart muscle, appendix, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells in bone marrow and spleen. Membranous expression in colon and rectum.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041820 , HPA046601
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Prostate
N/A
Female tissues
Vagina
N/A
Ovary
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (bone marrow, rectum, colon, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, colon, prostate, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, vagina, lymph node, heart muscle, appendix, lung)

GENE INFORMATION

Gene name

 CD177 (HGNC Symbol)

Synonyms

 HNA2A, NB1, PRV1

Description

 CD177 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

Chromosome

 19

Cytoband

 q13.31

Chromosome location (bp)

 43353659 - 43363172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204936 (version 83.38)

Entrez gene

 57126

UniProt

neXtProt

Antibodypedia

 CD177 antibodies

PROTEIN BROWSER
CD177-001
CD177-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD177-001
ENSP00000479536
ENST00000618265
A0A087WVM2 [Direct mapping]
CD177 antigen
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 437 aa
46.4 kDa 		Yes 0
CD177-002
ENSP00000483817
ENST00000607855
A0A087X113 [Direct mapping]
CD177 antigen
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 139 aa
15.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.