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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002064 [epithelial cell development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006884 [cell volume homeostasis] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008015 [blood circulation] GO:0008134 [transcription factor binding] GO:0008361 [regulation of cell size] GO:0009887 [organ morphogenesis] GO:0010467 [gene expression] GO:0019904 [protein domain specific binding] GO:0042127 [regulation of cell proliferation] GO:0042384 [cilium assembly] GO:0044458 [motile cilium assembly] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0098534 [centriole assembly] GO:1903251 [multi-ciliated epithelial cell differentiation]
