Expression of CPT1B in cancer - Summary

CANCER ATLAS

Gene description

Carnitine palmitoyltransferase 1B (muscle)

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029583

GENE INFORMATION
Gene name	CPT1B (HGNC Symbol)
Synonyms	CPT1-M, M-CPT1
Description	Carnitine palmitoyltransferase 1B (muscle) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	50568861 - 50578465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205560 (version 83.38)
Entrez gene	1375
UniProt	Q92523 (UniProt - Evidence at protein level)
neXtProt	NX_Q92523
Antibodypedia	CPT1B antibodies

PROTEIN BROWSER

CPT1B-001	CPT1B-004	CPT1B-005	CPT1B-008	CPT1B-201	CPT1B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPT1B-001 ENSP00000379011 ENST00000395650	Q92523 [Direct mapping] Carnitine O-palmitoyltransferase 1, muscle isoform A0A024R4W7 [Target identity:100%; Query identity:100%] HCG2044796, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0015909 [long-chain fatty acid transport] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	772 aa 87.8 kDa	No	2
CPT1B-004 ENSP00000312189 ENST00000312108	Q92523 [Direct mapping] Carnitine O-palmitoyltransferase 1, muscle isoform A0A024R4W7 [Target identity:100%; Query identity:100%] HCG2044796, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	772 aa 87.8 kDa	No	2
CPT1B-005 ENSP00000385486 ENST00000405237	Q92523 [Direct mapping] Carnitine O-palmitoyltransferase 1, muscle isoform A0A024R4W7 [Target identity:100%; Query identity:100%] HCG2044796, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	772 aa 87.8 kDa	No	2
CPT1B-008 ENSP00000406316 ENST00000417176	C9J7C3 [Direct mapping] Carnitine O-palmitoyltransferase 1, muscle isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] Show all	125 aa 13.8 kDa	No	2
CPT1B-201 ENSP00000353945 ENST00000360719	Q92523 [Direct mapping] Carnitine O-palmitoyltransferase 1, muscle isoform A0A024R4W7 [Target identity:100%; Query identity:100%] HCG2044796, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	772 aa 87.8 kDa	No	2
CPT1B-202 ENSP00000409342 ENST00000457250	Q92523 [Direct mapping] Carnitine O-palmitoyltransferase 1, muscle isoform Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	738 aa 83.9 kDa	No	2