Expression of HMGN1 in cancer - Summary

CANCER ATLAS

Gene description

High mobility group nucleosome binding domain 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA048694	CAB012260

GENE INFORMATION
Gene name	HMGN1 (HGNC Symbol)
Synonyms	FLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
Description	High mobility group nucleosome binding domain 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Chromosome	21
Cytoband	q22.2
Chromosome location (bp)	39342315 - 39349647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205581 (version 83.38)
Entrez gene	3150
UniProt	P05114 (UniProt - Evidence at protein level)
neXtProt	NX_P05114
Antibodypedia	HMGN1 antibodies

PROTEIN BROWSER

HMGN1-001	HMGN1-013	HMGN1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMGN1-001 ENSP00000370125 ENST00000380749	P05114 [Direct mapping] Non-histone chromosomal protein HMG-14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000720 [pyrimidine dimer repair by nucleotide-excision repair] GO:0000785 [chromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006325 [chromatin organization] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0010224 [response to UV-B] GO:0010225 [response to UV-C] GO:0031492 [nucleosomal DNA binding] GO:0032786 [positive regulation of DNA-templated transcription, elongation] GO:0040034 [regulation of development, heterochronic] GO:0048597 [post-embryonic camera-type eye morphogenesis] GO:0050678 [regulation of epithelial cell proliferation] Show all	100 aa 10.7 kDa	No	0
HMGN1-013 ENSP00000370123 ENST00000380747	A6NEL0 [Direct mapping] Non-histone chromosomal protein HMG-14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0031492 [nucleosomal DNA binding] Show all	116 aa 12.4 kDa	No	0
HMGN1-018 ENSP00000370124 ENST00000380748	A6NL93 [Direct mapping] Non-histone chromosomal protein HMG-14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0031492 [nucleosomal DNA binding] Show all	90 aa 9.5 kDa	No	0