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Rare cases of hepatocellular carcinoma, stomach, ovarian and breast cancers showed weak cytoplasmic positivity. Remaining cancers were negative.
GENE INFORMATION
Gene name
KLRC3 (HGNC Symbol)
Synonyms
NKG2-E
Description
Killer cell lectin-like receptor subfamily C, member 3 (HGNC Symbol)
Entrez gene summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
