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RNPS1

CANCER ATLAS

Gene description

 RNA binding protein S1, serine-rich domain

Protein class

 Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044014

GENE INFORMATION

Gene name

 RNPS1

Synonyms

Description

 RNA binding protein S1, serine-rich domain (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2253116 - 2268412

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205937 (version 83.38)

Entrez gene

 10921

UniProt

 Q15287 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15287

Antibodypedia

 RNPS1 antibodies

PROTEIN BROWSER
«
RNPS1-001
RNPS1-002
RNPS1-003
RNPS1-004
RNPS1-005
RNPS1-006
RNPS1-007
RNPS1-009
RNPS1-012
RNPS1-013
RNPS1-014
RNPS1-015
RNPS1-017
RNPS1-018
RNPS1-019
RNPS1-020
RNPS1-021
RNPS1-022
RNPS1-025
RNPS1-027
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNPS1-001
ENSP00000315859
ENST00000320225
Q15287 [Direct mapping]
RNA-binding protein with serine-rich domain 1
D3DU92 [Target identity:100%; Query identity:100%]
RNA binding protein S1; RNA binding protein S1, serine-rich domain, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
Show all
 305 aa
34.2 kDa 		No 0
RNPS1-002
ENSP00000456352
ENST00000566458
Q15287 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
Show all
 282 aa
31.7 kDa 		No 0
RNPS1-003
ENSP00000301730
ENST00000301730
Q15287 [Direct mapping]
RNA-binding protein with serine-rich domain 1
D3DU92 [Target identity:100%; Query identity:100%]
RNA binding protein S1; RNA binding protein S1, serine-rich domain, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
Show all
 305 aa
34.2 kDa 		No 0
RNPS1-004
ENSP00000455306
ENST00000561718
H3BPG5 [Direct mapping]
RNA binding protein S1, serine-rich domain, isoform CRA_c; RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 128 aa
15.1 kDa 		No 0
RNPS1-005
ENSP00000380275
ENST00000397086
Q15287 [Direct mapping]
RNA-binding protein with serine-rich domain 1
D3DU92 [Target identity:100%; Query identity:100%]
RNA binding protein S1; RNA binding protein S1, serine-rich domain, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
Show all
 305 aa
34.2 kDa 		No 0
RNPS1-006
ENSP00000457820
ENST00000568631
Q15287 [Direct mapping]
RNA-binding protein with serine-rich domain 1
D3DU92 [Target identity:100%; Query identity:100%]
RNA binding protein S1; RNA binding protein S1, serine-rich domain, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
Show all
 305 aa
34.2 kDa 		No 0
RNPS1-007
ENSP00000457723
ENST00000565678
Q15287 [Direct mapping]
RNA-binding protein with serine-rich domain 1
D3DU92 [Target identity:100%; Query identity:100%]
RNA binding protein S1; RNA binding protein S1, serine-rich domain, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
Show all
 305 aa
34.2 kDa 		No 0
RNPS1-009
ENSP00000455379
ENST00000566397
H3BPG5 [Direct mapping]
RNA binding protein S1, serine-rich domain, isoform CRA_c; RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 128 aa
15.1 kDa 		No 0
RNPS1-012
ENSP00000456283
ENST00000564822
H3BRK4 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.1 kDa 		No 0
RNPS1-013
ENSP00000457296
ENST00000562690
H3BTR6 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 127 aa
13 kDa 		No 0
RNPS1-014
ENSP00000454461
ENST00000561518
H3BMM9 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
Show all
 284 aa
31.7 kDa 		No 0
RNPS1-015
ENSP00000457690
ENST00000564601
H3BUL0 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 169 aa
18.2 kDa 		No 0
RNPS1-017
ENSP00000457618
ENST00000566180
H3BUG0 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 139 aa
14.6 kDa 		No 0
RNPS1-018
ENSP00000455195
ENST00000569709
H3BP82 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 98 aa
10.4 kDa 		No 0
RNPS1-019
ENSP00000454867
ENST00000565333
H3BNI3 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 85 aa
9.3 kDa 		No 0
RNPS1-020
ENSP00000457378
ENST00000564764
H3BTY0 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 150 aa
16 kDa 		No 0
RNPS1-021
ENSP00000457338
ENST00000565589
H3BTV0 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 45 aa
5.1 kDa 		No 0
RNPS1-022
ENSP00000457110
ENST00000565870
H3BTC0 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
Show all
 302 aa
33.9 kDa 		No 0
RNPS1-025
ENSP00000457987
ENST00000569598
H3BV80 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 211 aa
24.6 kDa 		No 0
RNPS1-027
ENSP00000454513
ENST00000567147
H3BMS0 [Direct mapping]
RNA-binding protein with serine-rich domain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 257 aa
27.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.