Cell atlas - DOK6 - The Human Protein Atlas

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DOK6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Focal adhesion sites

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	DOK6
Gene description	Docking protein 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & focal adhesion sites.
RNA cell category	Cell line enhanced (SH-SY5Y, Hep G2, RPMI-8226, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Focal adhesion sites (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063534
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, Hep G2, RPMI-8226, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & focal adhesion sites.

Main location

Focal adhesion sites (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063534	Hep G2	Focal adhesion sites
	HPA063534	SH-SY5Y	Cytosol
	HPA063534	U-2 OS	Focal adhesion sites
	HPA063534	U-2 OS	Cytosol

GENE INFORMATION
Gene name	DOK6 (HGNC Symbol)
Synonyms	DOK5L, HsT3226, MGC20785
Description	Docking protein 6 (HGNC Symbol)
Entrez gene summary	DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
Chromosome	18
Cytoband	q22.2
Chromosome location (bp)	69401055 - 69849087
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206052 (version 83.38)
Entrez gene	220164
UniProt	Q6PKX4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PKX4
Antibodypedia	DOK6 antibodies

PROTEIN BROWSER

DOK6-001	DOK6-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOK6-001 ENSP00000372160 ENST00000382713	Q6PKX4 [Direct mapping] Docking protein 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] Show all	331 aa 38.3 kDa	No	0
DOK6-005 ENSP00000462984 ENST00000582992	J3KTH4 [Direct mapping] Docking protein 6 Show all	Predicted intracellular proteins Show all	GO:0005158 [insulin receptor binding] Show all	156 aa 18.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.