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Several of cases of colorectal, breast and prostate cancer displayed weak to moderate granular cytoplasmic immunoreactivity with additional nuclear positivity in urothelial cancers and squamous cell carcinomas. Two cases of squamous cell carcinoma of cervix showed strong staining. Remaining cancer tissues were negative.
Most cancers showed weak to moderate cytoplasmic positivity with additional membranous positivity in many cases. Additional nuclear positivity was observed in squamous cell carcinomas. Cases of colorectal, endometrial, cervical, ovarian and lung cancers exhibited strong immunoreactivity. Lymphomas, renal cancers along with several cases of gliomas, melanomas and testicular cancers were negative.
Cervical squamous cell carcinomas as well as cases of bladder cancers and squamous cell carcinomas in lung and skin displayed moderate to strong cytoplasmic and nuclear positivity. Remaining cancers were negative.
GENE INFORMATION
Gene name
SERPINB4 (HGNC Symbol)
Synonyms
LEUPIN, PI11, SCCA-2, SCCA1, SCCA2
Description
Serpin peptidase inhibitor, clade B (ovalbumin), member 4 (HGNC Symbol)
MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)