Expression of HBA1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hemoglobin, alpha 1

Protein class

Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043780	CAB032534

GENE INFORMATION
Gene name	HBA1 (HGNC Symbol)
Synonyms	HBA-T3
Description	Hemoglobin, alpha 1 (HGNC Symbol)
Entrez gene summary	The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	176680 - 177522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206172 (version 83.38)
Entrez gene	3039
UniProt	P69905 (UniProt - Evidence at protein level)
neXtProt	NX_P69905
Antibodypedia	HBA1 antibodies

PROTEIN BROWSER

HBA1-001	HBA1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HBA1-001 ENSP00000322421 ENST00000320868	P69905 [Direct mapping] Hemoglobin subunit alpha D1MGQ2 [Target identity:100%; Query identity:100%] Alpha-2 globin chain; Delta globin; HCG1745306, isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004601 [peroxidase activity] GO:0005344 [oxygen transporter activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005833 [hemoglobin complex] GO:0006898 [receptor-mediated endocytosis] GO:0010942 [positive regulation of cell death] GO:0015671 [oxygen transport] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0031720 [haptoglobin binding] GO:0031838 [haptoglobin-hemoglobin complex] GO:0042542 [response to hydrogen peroxide] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0051291 [protein heterooligomerization] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0071682 [endocytic vesicle lumen] GO:0072562 [blood microparticle] Show all	142 aa 15.3 kDa	No	0
HBA1-006 ENSP00000380899 ENST00000397797	G3V1N2 [Direct mapping] HCG1745306, isoform CRA_a; Hemoglobin subunit alpha Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005344 [oxygen transporter activity] GO:0005506 [iron ion binding] GO:0005833 [hemoglobin complex] GO:0015671 [oxygen transport] GO:0019825 [oxygen binding] GO:0020037 [heme binding] Show all	110 aa 11.9 kDa	No	0