Expression of ATP10A in cancer - Summary

CANCER ATLAS

Gene description

ATPase, class V, type 10A

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041496	HPA042509

GENE INFORMATION
Gene name	ATP10A (HGNC Symbol)
Synonyms	ATP10C, ATPVA, ATPVC, KIAA0566
Description	ATPase, class V, type 10A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q12
Chromosome location (bp)	25677273 - 25865172
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206190 (version 83.38)
Entrez gene	57194
UniProt	O60312 (UniProt - Evidence at transcript level)
neXtProt	NX_O60312
Antibodypedia	ATP10A antibodies

PROTEIN BROWSER

ATP10A-001	ATP10A-004	ATP10A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP10A-001 ENSP00000349325 ENST00000356865	O60312 [Direct mapping] Probable phospholipid-transporting ATPase VA Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0008152 [metabolic process] GO:0008360 [regulation of cell shape] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	1499 aa 167.7 kDa	No	>9
ATP10A-004 ENSP00000451615 ENST00000555756	H0YJI4 [Direct mapping] Probable phospholipid-transporting ATPase VA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	139 aa 15.6 kDa	No	1
ATP10A-201 ENSP00000480665 ENST00000619904	O60312 [Direct mapping] Probable phospholipid-transporting ATPase VA Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0008152 [metabolic process] GO:0008360 [regulation of cell shape] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0045332 [phospholipid translocation] GO:0055085 [transmembrane transport] Show all	155 aa 17.6 kDa	No	3