Fields »
ABOUT
HELP
BLOG
HLA-A

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 HLA-A

Gene description

 Major histocompatibility complex, class I, A

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & the Golgi apparatus.

RNA cell category

 Cell line enhanced (A-431, U-266/70)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (approved), Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB078470
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431, U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & the Golgi apparatus.

Main location

 Golgi apparatus (approved), Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB078470 A-431 Golgi apparatus
Plasma membrane
CAB078470 HaCaT No staining    
CAB078470 U-2 OS No staining    

GENE INFORMATION

Gene name

 HLA-A

Synonyms

Description

 Major histocompatibility complex, class I, A (HGNC Symbol)

Entrez gene summary

 HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 29941260 - 29945884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000206503 (version 83.38)

Entrez gene

 3105

UniProt

 P04439 (UniProt - Evidence at protein level), P13746 (UniProt - Evidence at protein level), P16188 (UniProt - Evidence at protein level)

neXtProt

 NX_P04439, NX_P13746, NX_P16188

Antibodypedia

 HLA-A antibodies

PROTEIN BROWSER
HLA-A-001
HLA-A-002
HLA-A-003
HLA-A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HLA-A-001
ENSP00000379873
ENST00000396634
P04439 [Direct mapping]
HLA class I histocompatibility antigen, A-3 alpha chain
P13746 [Direct mapping]
HLA class I histocompatibility antigen, A-11 alpha chain
P16188 [Direct mapping]
HLA class I histocompatibility antigen, A-30 alpha chain
B1PKY1 [Target identity:100%; Query identity:100%]
MHC class I antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0030881 [beta-2-microglobulin binding]
GO:0031901 [early endosome membrane]
GO:0042270 [protection from natural killer cell mediated cytotoxicity]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042605 [peptide antigen binding]
GO:0042612 [MHC class I protein complex]
GO:0046977 [TAP binding]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
Show all
 365 aa
40.8 kDa 		Yes 1
HLA-A-002
ENSP00000366002
ENST00000376806
Q5SRN5 [Direct mapping]
HLA class I histocompatibility antigen, A-3 alpha chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0006955 [immune response]
GO:0016021 [integral component of membrane]
GO:0019882 [antigen processing and presentation]
GO:0042605 [peptide antigen binding]
GO:0042612 [MHC class I protein complex]
Show all
 371 aa
41.4 kDa 		Yes 1
HLA-A-003
ENSP00000365998
ENST00000376802
Q5SRN7 [Direct mapping]
HLA class I histocompatibility antigen, A-3 alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0006955 [immune response]
GO:0042605 [peptide antigen binding]
GO:0042612 [MHC class I protein complex]
Show all
 299 aa
34.2 kDa 		Yes 0
HLA-A-201
ENSP00000366005
ENST00000376809
P04439 [Direct mapping]
HLA class I histocompatibility antigen, A-3 alpha chain
P13746 [Direct mapping]
HLA class I histocompatibility antigen, A-11 alpha chain
P16188 [Direct mapping]
HLA class I histocompatibility antigen, A-30 alpha chain
B1PKY1 [Target identity:100%; Query identity:100%]
MHC class I antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0030881 [beta-2-microglobulin binding]
GO:0031901 [early endosome membrane]
GO:0042270 [protection from natural killer cell mediated cytotoxicity]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042605 [peptide antigen binding]
GO:0042612 [MHC class I protein complex]
GO:0046977 [TAP binding]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
Show all
 365 aa
40.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.