Tissue expression of DIO1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DIO1
Gene description	Deiodinase, iodothyronine, type I
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (thyroid gland, kidney, liver)
GTEx:	Tissue enhanced (thyroid gland, liver)
FANTOM5:	Group enriched (thyroid gland, liver, kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (thyroid gland, kidney, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (thyroid gland, liver, kidney)

GENE INFORMATION
Gene name	DIO1 (HGNC Symbol)
Synonyms	TXDI1
Description	Deiodinase, iodothyronine, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	53891239 - 53911086
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000211452 (version 83.38)
Entrez gene	1733
UniProt	P49895 (UniProt - Evidence at transcript level)
neXtProt	NX_P49895
Antibodypedia	DIO1 antibodies

PROTEIN BROWSER

DIO1-001	DIO1-002	DIO1-009	DIO1-010	DIO1-013	DIO1-014	DIO1-017	DIO1-201	DIO1-202	DIO1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIO1-001 ENSP00000354643 ENST00000361921	P49895 [Direct mapping] Type I iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	249 aa 28.9 kDa	No	1
DIO1-002 ENSP00000323198 ENST00000322679	P49895 [Direct mapping] Type I iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	161 aa 18.7 kDa	No	1
DIO1-009 ENSP00000373528 ENST00000388876	P49895 [Direct mapping] Type I iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	201 aa 23.4 kDa	No	1
DIO1-010 ENSP00000434758 ENST00000532493	P49895 [Direct mapping] Type I iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	113 aa 13.2 kDa	No	1
DIO1-013 ENSP00000435725 ENST00000525202	P49895 [Direct mapping] Type I iodothyronine deiodinase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0008430 [selenium binding] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042446 [hormone biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	185 aa 21.3 kDa	No	1
DIO1-014 ENSP00000434152 ENST00000524406	D3DQ42 [Direct mapping] Iodothyronine deiodinase Show all	Predicted intracellular proteins Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	120 aa 14 kDa	No	0
DIO1-017 ENSP00000432797 ENST00000529589	E9PNR3 [Direct mapping] Iodothyronine deiodinase Show all	Predicted intracellular proteins Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	184 aa 21.5 kDa	No	0
DIO1-201 ENSP00000483367 ENST00000610607	A0A087X0G2 [Direct mapping] Type I iodothyronine deiodinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	84 aa 9.1 kDa	No	1
DIO1-202 ENSP00000479755 ENST00000613679	A0A087WVX4 [Direct mapping] Iodothyronine deiodinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0016021 [integral component of membrane] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	248 aa 28.8 kDa	No	1
DIO1-203 ENSP00000481665 ENST00000617230	A0A087WYB0 [Direct mapping] Iodothyronine deiodinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004800 [thyroxine 5'-deiodinase activity] GO:0016021 [integral component of membrane] GO:0042446 [hormone biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	160 aa 18.6 kDa	No	1