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NUP62

CANCER ATLAS

Gene description

 Nucleoporin 62kDa

Protein class

 Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005435
CAB020724

GENE INFORMATION

Gene name

 NUP62 (HGNC Symbol)

Synonyms

 DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, p62, SNDI

Description

 Nucleoporin 62kDa (HGNC Symbol)

Entrez gene summary

 The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49906825 - 49929763

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213024 (version 83.38)

Entrez gene

 23636

UniProt

 P37198 (UniProt - Evidence at protein level)

neXtProt

 NX_P37198

Antibodypedia

 NUP62 antibodies

PROTEIN BROWSER
«
NUP62-001
NUP62-002
NUP62-003
NUP62-004
NUP62-005
NUP62-008
NUP62-013
NUP62-014
NUP62-015
NUP62-016
NUP62-017
NUP62-020
NUP62-023
NUP62-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUP62-001
ENSP00000305503
ENST00000352066
P37198 [Direct mapping]
Nuclear pore glycoprotein p62
A0A024QZF1 [Target identity:100%; Query identity:100%]
HCG19665, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003682 [chromatin binding]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008033 [tRNA processing]
GO:0008219 [cell death]
GO:0008285 [negative regulation of cell proliferation]
GO:0008645 [hexose transport]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031074 [nucleocytoplasmic shuttling complex]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046930 [pore complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:0090543 [Flemming body]
GO:1900034 [regulation of cellular response to heat]
Show all
 522 aa
53.3 kDa 		No 0
NUP62-002
ENSP00000473192
ENST00000597029
P37198 [Direct mapping]
Nuclear pore glycoprotein p62
A0A024QZF1 [Target identity:100%; Query identity:100%]
HCG19665, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003682 [chromatin binding]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008033 [tRNA processing]
GO:0008219 [cell death]
GO:0008285 [negative regulation of cell proliferation]
GO:0008645 [hexose transport]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031074 [nucleocytoplasmic shuttling complex]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046930 [pore complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:0090543 [Flemming body]
GO:1900034 [regulation of cellular response to heat]
Show all
 522 aa
53.3 kDa 		No 0
NUP62-003
ENSP00000471191
ENST00000596217
P37198 [Direct mapping]
Nuclear pore glycoprotein p62
A0A024QZF1 [Target identity:100%; Query identity:100%]
HCG19665, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003682 [chromatin binding]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006606 [protein import into nucleus]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008033 [tRNA processing]
GO:0008219 [cell death]
GO:0008285 [negative regulation of cell proliferation]
GO:0008645 [hexose transport]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019894 [kinesin binding]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031074 [nucleocytoplasmic shuttling complex]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0042306 [regulation of protein import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046930 [pore complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:0070208 [protein heterotrimerization]
GO:0090543 [Flemming body]
GO:1900034 [regulation of cellular response to heat]
Show all
 522 aa
53.3 kDa 		No 0
NUP62-004
ENSP00000407331
ENST00000422090
P37198 [Direct mapping]
Nuclear pore glycoprotein p62
A0A024QZF1 [Target identity:100%; Query identity:100%]
HCG19665, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003682 [chromatin binding]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008033 [tRNA processing]
GO:0008219 [cell death]
GO:0008285 [negative regulation of cell proliferation]
GO:0008645 [hexose transport]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030529 [ribonucleoprotein complex]
GO:0031047 [gene silencing by RNA]
GO:0031074 [nucleocytoplasmic shuttling complex]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046930 [pore complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:0090543 [Flemming body]
GO:1900034 [regulation of cellular response to heat]
Show all
 522 aa
53.3 kDa 		No 0
NUP62-005
ENSP00000469283
ENST00000597723
M0QXN5 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 446 aa
45.6 kDa 		No 0
NUP62-008
ENSP00000472081
ENST00000599567
M0R1S1 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
Show all
 100 aa
9.6 kDa 		No 0
NUP62-013
ENSP00000472918
ENST00000593652
M0R302 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 138 aa
13.2 kDa 		No 0
NUP62-014
ENSP00000470157
ENST00000594673
M0QYY0 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
Show all
 36 aa
3.5 kDa 		No 0
NUP62-015
ENSP00000468884
ENST00000599788
A0A0E3D6N6 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 24 aa
2.3 kDa 		No 0
NUP62-016
ENSP00000468839
ENST00000600935
M0QX10 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 23 aa
2.2 kDa 		No 0
NUP62-017
ENSP00000471133
ENST00000596680
M0R0B7 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 19 aa
1.8 kDa 		No 0
NUP62-020
ENSP00000468842
ENST00000596437
M0QX13 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
Show all
 75 aa
7.3 kDa 		No 0
NUP62-023
ENSP00000468930
ENST00000595761
M0QX64 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 134 aa
12.8 kDa 		No 0
NUP62-024
ENSP00000470624
ENST00000600645
M0QZL5 [Direct mapping]
Nuclear pore glycoprotein p62
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0017056 [structural constituent of nuclear pore]
Show all
 99 aa
9.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.