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SUPT4H1

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GENERAL INFORMATION

Gene name

 SUPT4H1

Gene description

 SPT4 homolog, DSIF elongation factor subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA059748
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA059748 HEK 293 Nucleus
HPA059748 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 SUPT4H1 (HGNC Symbol)

Synonyms

 Spt4, SPT4H, Supt4a, SUPT4H

Description

 SPT4 homolog, DSIF elongation factor subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 58345175 - 58353093

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213246 (version 83.38)

Entrez gene

 6827

UniProt

 P63272 (UniProt - Evidence at protein level)

neXtProt

 NX_P63272

Antibodypedia

 SUPT4H1 antibodies

PROTEIN BROWSER
SUPT4H1-001
SUPT4H1-002
SUPT4H1-005
SUPT4H1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUPT4H1-001
ENSP00000225504
ENST00000225504
P63272 [Direct mapping]
Transcription elongation factor SPT4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032044 [DSIF complex]
GO:0032785 [negative regulation of DNA-templated transcription, elongation]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0050434 [positive regulation of viral transcription]
Show all
 117 aa
13.2 kDa 		No 0
SUPT4H1-002
ENSP00000462100
ENST00000577396
D3DTZ5 [Direct mapping]
Suppressor of Ty 4 homolog 1 (S. cerevisiae), isoform CRA_b; Transcription elongation factor SPT4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
Show all
 76 aa
8.5 kDa 		No 0
SUPT4H1-005
ENSP00000464618
ENST00000581540
J3QSB9 [Direct mapping]
Transcription elongation factor SPT4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
Show all
 108 aa
12.3 kDa 		No 0
SUPT4H1-006
ENSP00000462670
ENST00000580947
P63272 [Direct mapping]
Transcription elongation factor SPT4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032044 [DSIF complex]
GO:0032785 [negative regulation of DNA-templated transcription, elongation]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0050434 [positive regulation of viral transcription]
Show all
 117 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.