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SIPA1

GENERAL INFORMATION

Gene name

 SIPA1

Gene description

 Signal-induced proliferation-associated 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA039867 , CAB020833
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SIPA1 (HGNC Symbol)

Synonyms

 SPA1

Description

 Signal-induced proliferation-associated 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65585395 - 65650930

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213445 (version 83.38)

Entrez gene

 6494

UniProt

 Q96FS4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96FS4

Antibodypedia

 SIPA1 antibodies

PROTEIN BROWSER
SIPA1-001
SIPA1-002
SIPA1-003
SIPA1-004
SIPA1-005
SIPA1-201
SIPA1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIPA1-001
ENSP00000436269
ENST00000534313
Q96FS4 [Direct mapping]
Signal-induced proliferation-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0008283 [cell proliferation]
GO:0030308 [negative regulation of cell growth]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1042 aa
112.1 kDa 		No 0
SIPA1-002
ENSP00000433686
ENST00000527525
F6RY50 [Direct mapping]
Signal-induced proliferation-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 940 aa
101.8 kDa 		No 0
SIPA1-003
ENSP00000377771
ENST00000394224
Q96FS4 [Direct mapping]
Signal-induced proliferation-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0030133 [transport vesicle]
GO:0030308 [negative regulation of cell growth]
GO:0035556 [intracellular signal transduction]
GO:0042631 [cellular response to water deprivation]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 1042 aa
112.1 kDa 		No 0
SIPA1-004
ENSP00000436683
ENST00000533361
E9PIB3 [Direct mapping]
Signal-induced proliferation-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 103 aa
11 kDa 		No 0
SIPA1-005
ENSP00000434362
ENST00000526137
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 6 aa
0.7 kDa 		No 0
SIPA1-201
ENSP00000377774
ENST00000394227
Q96FS4 [Direct mapping]
Signal-induced proliferation-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0008283 [cell proliferation]
GO:0030308 [negative regulation of cell growth]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0045786 [negative regulation of cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1042 aa
112.1 kDa 		No 0
SIPA1-202
ENSP00000485899
ENST00000628801
F6RY50 [Direct mapping]
Signal-induced proliferation-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 940 aa
101.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.