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Most cancer tissues displayed weak to moderate cytoplasmic immunoreactivity with additional nuclear positivity in few cases. Testicular and renal cancers were generally negative.
Most cancer tissues showed moderate cytoplasmic and nuclear immunoreactivity. Several gliomas and carcinoids along with a few prostate cancers were strongly stained.
GENE INFORMATION
Gene name
SRA1 (HGNC Symbol)
Synonyms
SRA, STRAA1
Description
Steroid receptor RNA activator 1 (HGNC Symbol)
Entrez gene summary
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]