Fields »
ABOUT
HELP
BLOG
PPP1CB

GENERAL INFORMATION

Gene name

 PPP1CB

Gene description

 Protein phosphatase 1, catalytic subunit, beta isozyme

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA065425 , CAB069426
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPP1CB (HGNC Symbol)

Synonyms

 PP-1B, PP1B, PP1beta

Description

 Protein phosphatase 1, catalytic subunit, beta isozyme (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.2

Chromosome location (bp)

 28751640 - 28802940

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213639 (version 83.38)

Entrez gene

 5500

UniProt

 P62140 (UniProt - Evidence at protein level)

neXtProt

 NX_P62140

Antibodypedia

 PPP1CB antibodies

PROTEIN BROWSER
PPP1CB-001
PPP1CB-003
PPP1CB-004
PPP1CB-005
PPP1CB-006
PPP1CB-009
PPP1CB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1CB-001
ENSP00000378769
ENST00000395366
P62140 [Direct mapping]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
V9HW04 [Target identity:100%; Query identity:100%]
Serine/threonine-protein phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000164 [protein phosphatase type 1 complex]
GO:0000278 [mitotic cell cycle]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005977 [glycogen metabolic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0005981 [regulation of glycogen catabolic process]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017018 [myosin phosphatase activity]
GO:0019433 [triglyceride catabolic process]
GO:0019901 [protein kinase binding]
GO:0030155 [regulation of cell adhesion]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0042587 [glycogen granule]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050115 [myosin-light-chain-phosphatase activity]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070688 [MLL5-L complex]
GO:0072357 [PTW/PP1 phosphatase complex]
Show all
 327 aa
37.2 kDa 		No 0
PPP1CB-003
ENSP00000296122
ENST00000296122
P62140 [Direct mapping]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
V9HW04 [Target identity:100%; Query identity:100%]
Serine/threonine-protein phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005977 [glycogen metabolic process]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017018 [myosin phosphatase activity]
GO:0019433 [triglyceride catabolic process]
GO:0019901 [protein kinase binding]
GO:0030155 [regulation of cell adhesion]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050115 [myosin-light-chain-phosphatase activity]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070688 [MLL5-L complex]
GO:0072357 [PTW/PP1 phosphatase complex]
Show all
 327 aa
37.2 kDa 		No 0
PPP1CB-004
ENSP00000390715
ENST00000455580
E7ETD8 [Direct mapping]
Serine/threonine-protein phosphatase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016787 [hydrolase activity]
Show all
 169 aa
19.6 kDa 		No 0
PPP1CB-005
ENSP00000414918
ENST00000441461
C9JP48 [Direct mapping]
Serine/threonine-protein phosphatase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016787 [hydrolase activity]
Show all
 138 aa
15.8 kDa 		No 0
PPP1CB-006
ENSP00000398839
ENST00000420282
C9J9S3 [Direct mapping]
Serine/threonine-protein phosphatase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016787 [hydrolase activity]
Show all
 125 aa
14.3 kDa 		No 0
PPP1CB-009
ENSP00000388056
ENST00000418910
H0Y3Y6 [Direct mapping]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 82 aa
9.8 kDa 		No 0
PPP1CB-201
ENSP00000351298
ENST00000358506
P62140 [Direct mapping]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
V9HW04 [Target identity:100%; Query identity:100%]
Serine/threonine-protein phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005977 [glycogen metabolic process]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017018 [myosin phosphatase activity]
GO:0019433 [triglyceride catabolic process]
GO:0019901 [protein kinase binding]
GO:0030155 [regulation of cell adhesion]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050115 [myosin-light-chain-phosphatase activity]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070688 [MLL5-L complex]
GO:0072357 [PTW/PP1 phosphatase complex]
Show all
 327 aa
37.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.