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A few hepatocellular carcinomas, thyroid, ovarian and colorectal cancers displayed weak to moderate cytoplasmic and nuclear positivity. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
SULT1A4
Synonyms
Description
Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 (HGNC Symbol)
Entrez gene summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]