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CLIC1

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GENERAL INFORMATION

Gene name

 CLIC1

Gene description

 Chloride intracellular channel 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB040557
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB040557 A-431 Cytosol
CAB040557 U-2 OS Cytosol
CAB040557 U-251 MG Cytosol

GENE INFORMATION

Gene name

 CLIC1 (HGNC Symbol)

Synonyms

 NCC27, p64CLCP

Description

 Chloride intracellular channel 1 (HGNC Symbol)

Entrez gene summary

 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31730581 - 31739763

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213719 (version 83.38)

Entrez gene

 1192

UniProt

 O00299 (UniProt - Evidence at protein level)

neXtProt

 NX_O00299

Antibodypedia

 CLIC1 antibodies

PROTEIN BROWSER
CLIC1-001
CLIC1-002
CLIC1-003
CLIC1-004
CLIC1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC1-001
ENSP00000364940
ENST00000375784
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-002
ENSP00000364935
ENST00000375780
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-003
ENSP00000379229
ENST00000395892
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-004
ENSP00000364934
ENST00000375779
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0
CLIC1-202
ENSP00000479808
ENST00000616760
O00299 [Direct mapping]
Chloride intracellular channel protein 1
Q5SRT3 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006821 [chloride transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:1902476 [chloride transmembrane transport]
Show all
 241 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.