Cell atlas - DDAH2 - The Human Protein Atlas

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DDAH2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubule organizing center

Human cell
	Centrosome
	Cytosol

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GENERAL INFORMATION
Gene name	DDAH2
Gene description	Dimethylarginine dimethylaminohydrolase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the microtubule organizing center.
RNA cell category	Cell line enhanced (EFO-21, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)
Additional location	In addition localized to the Microtubule organizing center (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA012509
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the microtubule organizing center.

Main location

Cytosol (uncertain)

Additional location

Microtubule organizing center (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012509	A-431	Cytosol
	HPA012509	ASC TERT1	Microtubule organizing center
	HPA012509	ASC TERT1	Cytosol
	HPA012509	U-251 MG	Microtubule organizing center
	HPA012509	U-251 MG	Cytosol

GENE INFORMATION
Gene name	DDAH2
Synonyms
Description	Dimethylarginine dimethylaminohydrolase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31727038 - 31730617
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213722 (version 83.38)
Entrez gene	23564
UniProt	O95865 (UniProt - Evidence at protein level)
neXtProt	NX_O95865
Antibodypedia	DDAH2 antibodies

PROTEIN BROWSER

DDAH2-001	DDAH2-002	DDAH2-004	DDAH2-007	DDAH2-008	DDAH2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDAH2-001 ENSP00000364949 ENST00000375792	O95865 [Direct mapping] N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 V9HW53 [Target identity:100%; Query identity:100%] Dimethylarginine dimethylaminohydrolase 2, isoform CRA_a; Epididymis secretory protein Li 277 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000052 [citrulline metabolic process] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006527 [arginine catabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0007263 [nitric oxide mediated signal transduction] GO:0016403 [dimethylargininase activity] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	285 aa 29.6 kDa	No	0
DDAH2-002 ENSP00000364945 ENST00000375789	O95865 [Direct mapping] N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 V9HW53 [Target identity:100%; Query identity:100%] Dimethylarginine dimethylaminohydrolase 2, isoform CRA_a; Epididymis secretory protein Li 277 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000052 [citrulline metabolic process] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006525 [arginine metabolic process] GO:0006527 [arginine catabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0007263 [nitric oxide mediated signal transduction] GO:0016403 [dimethylargininase activity] GO:0016597 [amino acid binding] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	285 aa 29.6 kDa	No	0
DDAH2-004 ENSP00000364943 ENST00000375787	O95865 [Direct mapping] N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 V9HW53 [Target identity:100%; Query identity:100%] Dimethylarginine dimethylaminohydrolase 2, isoform CRA_a; Epididymis secretory protein Li 277 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000052 [citrulline metabolic process] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006527 [arginine catabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0007263 [nitric oxide mediated signal transduction] GO:0016403 [dimethylargininase activity] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	285 aa 29.6 kDa	No	0
DDAH2-007 ENSP00000397466 ENST00000416410	Q5SRR8 [Direct mapping] N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	236 aa 24.6 kDa	No	0
DDAH2-008 ENSP00000395759 ENST00000436437	Q5SSV3 [Direct mapping] N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	226 aa 23.6 kDa	No	0
DDAH2-010 ENSP00000413164 ENST00000437288	H0Y7N1 [Direct mapping] N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 20 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.