Expression of DNASE1 in cancer - Summary

CANCER ATLAS

Gene description

Deoxyribonuclease I

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA010703

GENE INFORMATION
Gene name	DNASE1 (HGNC Symbol)
Synonyms	DNL1
Description	Deoxyribonuclease I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE11 through DNASE16, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	3611728 - 3680143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213918 (version 83.38)
Entrez gene	1773
UniProt	P24855 (UniProt - Evidence at protein level)
neXtProt	NX_P24855
Antibodypedia	DNASE1 antibodies

PROTEIN BROWSER

DNASE1-001	DNASE1-005	DNASE1-014	DNASE1-015	DNASE1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNASE1-001 ENSP00000246949 ENST00000246949	P24855 [Direct mapping] Deoxyribonuclease-1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0003779 [actin binding] GO:0004520 [endodeoxyribonuclease activity] GO:0004530 [deoxyribonuclease I activity] GO:0004536 [deoxyribonuclease activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0006308 [DNA catabolic process] GO:0006915 [apoptotic process] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] GO:0070062 [extracellular exosome] Show all	282 aa 31.4 kDa	Yes	0
DNASE1-005 ENSP00000385905 ENST00000407479	P24855 [Direct mapping] Deoxyribonuclease-1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0003779 [actin binding] GO:0004520 [endodeoxyribonuclease activity] GO:0004530 [deoxyribonuclease I activity] GO:0004536 [deoxyribonuclease activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0006308 [DNA catabolic process] GO:0006915 [apoptotic process] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] GO:0070062 [extracellular exosome] Show all	282 aa 31.4 kDa	Yes	0
DNASE1-014 ENSP00000461129 ENST00000576792	I3L4B8 [Direct mapping] Deoxyribonuclease-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005634 [nucleus] GO:0006308 [DNA catabolic process] Show all	72 aa 7.8 kDa	No	0
DNASE1-015 ENSP00000461153 ENST00000575479	I3L4C7 [Direct mapping] Deoxyribonuclease-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0004520 [endodeoxyribonuclease activity] GO:0005634 [nucleus] Show all	65 aa 6.8 kDa	No	0
DNASE1-016 ENSP00000459507 ENST00000570664	I3L298 [Direct mapping] Deoxyribonuclease-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005634 [nucleus] GO:0006308 [DNA catabolic process] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] Show all	108 aa 12.3 kDa	No	0