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Hepatocellular carcinomas along with occasional cases of renal cancers showed moderate to strong cytoplasmic positivity in a granular pattern. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
HBG1 (HGNC Symbol)
Synonyms
HBG-T2
Description
Hemoglobin, gamma A (HGNC Symbol)
Entrez gene summary
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
