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AP1G2

GENERAL INFORMATION

Gene name

 AP1G2

Gene description

 Adaptor-related protein complex 1, gamma 2 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004106
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Appendix
N/A
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AP1G2 (HGNC Symbol)

Synonyms

 G2AD

Description

 Adaptor-related protein complex 1, gamma 2 subunit (HGNC Symbol)

Entrez gene summary

 Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23559565 - 23568070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213983 (version 83.38)

Entrez gene

 8906

UniProt

 O75843 (UniProt - Evidence at protein level)

neXtProt

 NX_O75843

Antibodypedia

 AP1G2 antibodies

PROTEIN BROWSER
AP1G2-002
AP1G2-003
AP1G2-017
AP1G2-032
AP1G2-036

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1G2-002
ENSP00000312442
ENST00000308724
O75843 [Direct mapping]
AP-1 complex subunit gamma-like 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030121 [AP-1 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030133 [transport vesicle]
GO:0061024 [membrane organization]
Show all
 785 aa
87.1 kDa 		No 0
AP1G2-003
ENSP00000380309
ENST00000397120
O75843 [Direct mapping]
AP-1 complex subunit gamma-like 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030121 [AP-1 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030133 [transport vesicle]
GO:0061024 [membrane organization]
Show all
 785 aa
87.1 kDa 		No 0
AP1G2-017
ENSP00000450805
ENST00000554477
H0YJ47 [Direct mapping]
AP-1 complex subunit gamma-like 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 197 aa
21 kDa 		No 0
AP1G2-032
ENSP00000451504
ENST00000556843
G3V3Z2 [Direct mapping]
AP-1 complex subunit gamma-like 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 137 aa
15.4 kDa 		No 0
AP1G2-036
ENSP00000452153
ENST00000557189
G3V532 [Direct mapping]
AP-1 complex subunit gamma-like 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 200 aa
22.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.