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Malignant cells displayed moderate cytoplasmic staining with additional nuclear staining in a few tissues. Most testicular and breast cancers along with several urothelial, colorectal, pancreatic and ovarian cancers were strongly stained. Most malignant lymphomas were negative.
GENE INFORMATION
Gene name
MYCBP (HGNC Symbol)
Synonyms
AMY-1
Description
MYC binding protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
