Expression of ALG3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

ALG3, alpha-1,3- mannosyltransferase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045103

GENE INFORMATION
Gene name	ALG3 (HGNC Symbol)
Synonyms	CDGS4, D16Ertd36e, Not56, NOT56L
Description	ALG3, alpha-1,3- mannosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	184242301 - 184249548
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214160 (version 83.38)
Entrez gene	10195
UniProt	Q92685 (UniProt - Evidence at protein level)
neXtProt	NX_Q92685
Antibodypedia	ALG3 antibodies

PROTEIN BROWSER

ALG3-001	ALG3-002	ALG3-003	ALG3-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG3-001 ENSP00000380793 ENST00000397676	Q92685 [Direct mapping] Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000033 [alpha-1,3-mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0052925 [dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity] GO:0097502 [mannosylation] Show all	438 aa 50.1 kDa	No	9
ALG3-002 ENSP00000402744 ENST00000445626	Q92685 [Direct mapping] Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000033 [alpha-1,3-mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0052925 [dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity] GO:0097502 [mannosylation] Show all	390 aa 44.4 kDa	No	8
ALG3-003 ENSP00000397613 ENST00000455059	C9J7S5 [Direct mapping] Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] Show all	398 aa 45.7 kDa	No	8
ALG3-014 ENSP00000397326 ENST00000446569	H7C0X4 [Direct mapping] Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] Show all	323 aa 36.9 kDa	No	8