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ARHGEF28

CANCER ATLAS

Gene description

 Rho guanine nucleotide exchange factor (GEF) 28

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037602

GENE INFORMATION

Gene name

 ARHGEF28 (HGNC Symbol)

Synonyms

 p190RhoGEF, RGNEF, RIP2

Description

 Rho guanine nucleotide exchange factor (GEF) 28 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 73626158 - 73941993

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000214944 (version 83.38)

Entrez gene

 64283

UniProt

 Q8N1W1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N1W1

Antibodypedia

 ARHGEF28 antibodies

PROTEIN BROWSER
ARHGEF28-001
ARHGEF28-004
ARHGEF28-005
ARHGEF28-006
ARHGEF28-007
ARHGEF28-009
ARHGEF28-201
ARHGEF28-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF28-001
ENSP00000296794
ENST00000296794
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1651 aa
185.8 kDa 		No 0
ARHGEF28-004
ENSP00000412175
ENST00000426542
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1705 aa
191.9 kDa 		No 0
ARHGEF28-005
ENSP00000411459
ENST00000437974
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1731 aa
194.5 kDa 		No 0
ARHGEF28-006
ENSP00000421081
ENST00000512883
D6RGZ3 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 651 aa
73.9 kDa 		No 0
ARHGEF28-007
ENSP00000296799
ENST00000296799
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1392 aa
157.3 kDa 		No 0
ARHGEF28-009
ENSP00000421859
ENST00000509848
D6RAP0 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
9.4 kDa 		No 0
ARHGEF28-201
ENSP00000441436
ENST00000513042
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 1705 aa
191.9 kDa 		No 0
ARHGEF28-202
ENSP00000441913
ENST00000545377
Q8N1W1 [Direct mapping]
Rho guanine nucleotide exchange factor 28
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0060052 [neurofilament cytoskeleton organization]
Show all
 1731 aa
194.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.